在表面活性剂稳定水性悬浮液的联合喷雾干燥后表面活性剂的干燥行为和表面活性剂的可视化
E De Pauw1, Y Chen2, H De Keersmaecker3
1Ghent University, Laboratory of Pharmaceutical Technology, Ottergemsesteenweg 460, 9000 Ghent, Belgium.
International journal of pharmaceutics
|July 24, 2023
概括
聚酸盐80 (PS80) 可以在联合喷雾干燥过程中引起粘性粉末,导致大量的材料损失. 它的表面丰富取决于工艺条件和原料特性.
科学领域:
- 制药技术 制药技术 制药技术
- 材料科学 材料科学 材料科学
背景情况:
- 表面活性剂是常见的悬浮剂工业添加剂.
- 聚酸盐80 (PS80) 是一种广泛使用的表面活性剂.
- 它们在药物填充剂组合的联合喷雾干燥中的作用需要研究.
研究的目的:
- 评估聚酸盐80 (PS80) 作为联合喷雾干燥药物填充剂悬浮物的稳定剂.
- 为了研究PS80在各种工艺和配方条件下的干燥行为.
主要方法:
- 含有药物填充剂和PS80的水性悬浮液的联合喷雾干燥.
- 使用光标记的PS80绘制它的分布图.
- 量化粉末损失和分析颗粒表面组成.
主要成果:
- 与0.1%的PS80联合喷雾干燥导致干燥设备中的过度粘性粉末损失 (高达16%).
- 粉末沉积与PS80在颗粒表面的存在相关.
- 在低悬浮分数和快速干燥条件下,PS80表面丰富度最高.
结论:
- 聚酸盐80 (PS80) 不是理想的稳定药物填充剂悬浮剂在联合喷雾干燥期间由于粘性.
- 工艺参数显著影响PS80的再分配和表面丰富.
- 在喷雾干燥中使用PS80时,需要仔细控制配方和工艺条件.
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