通过CTC检测和全外体测序,可以区分良性和恶性肺结节
Changdan Xu1, Xiaohong Xu2, Weipeng Shao3
1Department of Radiation Oncology, Peking University China-Japan Friendship School of Clinical Medicine, Beijing 100029, China.
Zhongguo fei ai za zhi = Chinese journal of lung cancer
|July 24, 2023
概括
循环瘤细胞 (CTC) 在区分恶性和良性肺结节方面表现有前途. 在CTC中TP53突变可能有助于早期肺癌诊断,补充成像技术.
科学领域:
- 在瘤学瘤学.
- 肺部病理学 肺部病理学
- 遗传学 是一个遗传学.
背景情况:
- 低剂量计算机断层扫描 (LDCT) 有助于早期发现肺癌,但产生错误阳性.
- 精确区分恶性和良性肺结节仍然是一个临床挑战.
研究的目的:
- 评估使用循环瘤细胞 (CTC) 来区分恶性和良性肺结节的可行性.
- 分析疑似肺结节患者中CTC的诊断性能和基因组资料.
主要方法:
- 122名怀疑患有恶性肺结节的患者在手术前接受了外周血液采集.
- 循环瘤细胞 (CTC) 通过大小和形态分析被分离和识别.
- 在选择的样本上进行了全外因组测序,以分析基因组变异.
主要成果:
- CTC 显示出诊断效率,ROC 曲线下的面积为 0.651 (灵敏度为 0.526,特异性为 0.800).
- 在良性和恶性CTC样本之间观察到明显的基因组变异,包括TP53突变.
- 特定的TP53突变 (g.7578115T>C,g.7578645C>T,g.7579472G>C) 仅在恶性病例中发现.
结论:
- 循环瘤细胞 (CTC) 作为肺结节诊断中的辅助工具.
- 在CTC中检测到的TP53突变显示出区分良性和恶性肺结节的潜力.
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