一个烧伤和COVID-19共享的应激反应基因网络解密CD1C-CD141-DCs作为性预后的关键细胞组件
Qiao Liang1, Lei Wang2, Jing Xu1
1Center for Translational Medicine and Jiangsu Key Laboratory of Molecular Medicine, Medical School of Nanjing University, Nanjing, 210093, Jiangsu Province, China.
Cell death discovery
|July 24, 2023
概括
研究人员确定了一个应激反应核心 (SRC) 基因网络,在烧伤和COVID-19中共同表达,与更好的结果相关. 这种网络主要在单细胞和树突细胞中,可能为免疫反应调节提供新的诊断和治疗点.
科学领域:
- 免疫学 免疫学 免疫学
- 基因组学就是基因组学.
- 系统生物学 系统生物学
背景情况:
- 对压力的不同反应 (传染性/非传染性) 影响临床结果.
- 跨刺激的压力反应的共同分子基础仍然不清楚.
- 周围血液免疫细胞反映系统状态,使它们成为研究应激反应的理想选择.
研究的目的:
- 确定燃烧和COVID-19中压力反应的共同分子和细胞机制.
- 调查已识别的基因网络的预后价值.
- 在COVID-19中探索这些网络的蜂源和功能特征.
主要方法:
- 来自烧伤和COVID-19患者的外周血液的转录组分析.
- 鉴定了一个以CD86为中心的共同表达的基因网络,称为应激反应核心 (SRC).
- 从COVID-19患者的全血中单细胞RNA测序,以确定SRC的细胞来源.
主要成果:
- 一个应激反应核心 (SRC) 基因网络在烧伤和COVID-19患者中被强烈共同表达.
- 增强的SRC基因表达与两种疾病的良好预后和降低严重程度相关.
- 单细胞状细胞 (Mono-DC) 种群是SRC的主要来源;单细胞中较高的SRC与无症状COVID-19相关.
- 减少的CD1C-CD141-状细胞 (DCs) 和它们的SRC表达与COVID-19中较差的临床结果相关,显示IFN信号静止和免疫失活.
结论:
- 在Mono-DC中确定了一个预后性,表达同步的基因网络.
- 该SRC网络,特别是在Mono-DCs,作为疾病严重程度和预后的潜在生物标志物.
- 这一以Mono-DC为中心的网络代表了与压力相关的疾病诊断和治疗的新目标.
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