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Updated: Jul 26, 2026

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在人类阿尔茨海默氏症大脑中检测,可视化和量化蛋白质复合体,使用近距离结合试验

Wilber Romero-Fernandez1, Cristian Carvajal-Tapia2, Alex Prusky2

  • 1Department of Neurology, Vanderbilt University Medical Center, MRBIII 465 21St Avenue S, Suite 6158, Nashville, TN, 37240, USA. wilber.romero.fernandez@vumc.org.

Scientific reports
|July 24, 2023
PubMed
概括

研究人员调整了近距离结合试验 (PLA) 来检测阿尔茨海默氏症患者的泛素修饰的蛋白.

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Alzheimer Disease ll: Pathophysiology01:23

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Alzheimer disease involves structural changes in the brain that begin long before symptoms appear. The most distinctive features are extracellular neuritic plaques and intracellular neurofibrillary tangles.Neuritic plaques form in the cerebral cortex and around blood vessels. These plaques contain a dense core of beta-amyloid (Aβ)—a toxic protein fragment that clumps outside neurons. The core is surrounded by damaged neuronal extensions, as well as reactive astrocytes and microglia. Abnormal...