相关实验视频
Updated: Jun 25, 2026

09:12
A Pre-Clinical Porcine Model of Orthotopic Heart Transplantation
Published on: April 27, 2019
9.6K
在两个最近去世的人类接受者身上,从猪到人类的心脏的异种移植
Nader Moazami1, Jeffrey M Stern2, Karen Khalil2
1Department of Cardiothoracic Surgery, New York University Langone Health, New York, NY, USA. nader.moazami@nyulangone.org.
Nature medicine
|July 24, 2023
概括
转基因猪心脏被移植到两个脑死亡的接受者身上. 异种移植的功能良好,没有表现出排斥或动物感染的迹象,为未来的异种移植研究铺平了道路.
科学领域:
- 移植生物学 移植生物学
- 基因工程生物体 基因工程生物体
- 免疫学 免疫学 免疫学
背景情况:
- 对于人类器官移植而言,存在着严重的器官短缺.
- 使用动物器官的异种移植提供了一个潜在的解决方案.
- 之前从猪移植到人类的心脏移植的数量有限.
研究的目的:
- 评估猪对人类心脏异种移植的可行性和安全性.
- 为了监测异种移植功能和受体反应.
- 为了评估排斥和动物传播.
主要方法:
- 将10个基因编辑的猪心脏移植到两个脑死亡的人体接受者身上.
- 对异种移植功能,血液动力学和全身反应进行66小时的监测.
- 评估转基因表达,排斥 (组织学,流细胞计,交叉匹配) 和动物病.
主要成果:
- 这两种猪心都表现出了出色的初始功能.
- 没有发现细胞或抗体介导排斥的证据.
- 在捐赠猪和接受者之间没有检测到动物传播.
- 一种异种移植由于尺寸不匹配而经历了术后衰退.
结论:
- 猪对人类的心脏异种移植是可行的,没有超急性排斥或动物感染.
- 为了临床应用,需要进一步的研究.
- 基因编辑的猪心脏显示出解决器官短缺问题的前景.
相关概念视频
Viral Recombination
Cells are sometimes infected by more than one virus at once. When two viruses disassemble to expose their genomes for replication in the same cell, similar regions of their genomes can pair together and exchange sequences in a process called recombination. Alternatively, viruses with segmented genomes can swap segments in a process called reassortment.
Types of Genetic Transfer Between Organisms
Genetic transfer occurs when genetic information is passed from one organism to another. It occurs via two mechanisms: vertical gene transfer and horizontal gene transfer. Vertical gene transfer occurs when genetic information is transferred from one generation to the next, which happens much more frequently than horizontal gene transfer. Both sexual and asexual reproduction are forms of vertical gene transfer, where one or more organisms pass some or all of their genome onto their progeny.
Types of Genetic Transfer Between Organisms
Genetic transfer occurs when genetic information is passed from one organism to another. It occurs via two mechanisms: vertical gene transfer and horizontal gene transfer. Vertical gene transfer occurs when genetic information is transferred from one generation to the next, which happens much more frequently than horizontal gene transfer. Both sexual and asexual reproduction are forms of vertical gene transfer, where one or more organisms pass some or all of their genome onto their progeny.
Tissue Transplantation
Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...

