神经性厌食症女性的psilocybin治疗:一个第一阶段,开放标签可行性研究
Stephanie Knatz Peck1, Samantha Shao2, Tessa Gruen2,3
1Department of Psychiatry, Eating Disorder Treatment & Research Center, University of California, San Diego, San Diego, CA, USA. sknatz@health.ucsd.edu.
Nature medicine
|July 24, 2023
概括
псилоцибин治疗显示出作为一种安全和可接受的治疗神经性厌食症 (AN) 的承诺. 这项可行性研究发现,在患有AN的成年女性中,迷幻疗法被很好地容忍,这表明了新的治疗方法的潜力.
科学领域:
- 精神病学是一个精神病学.
- 临床心理学 临床心理学
- 药理学 药理学是指药理学的学科.
背景情况:
- 神经性厌食症 (AN) 是一种严重的饮食障碍,有效治疗方法有限.
- 迫切需要新的治疗干预措施来改善AN的结果.
- 目前对AN的治疗选择缺乏FDA批准的治疗核心症状的药物.
研究的目的:
- 评估精神性厌食症的成年女性psilocybin治疗的安全性,耐受性和可行性.
- 为了评估不良事件 (AEs) 和生理测量和自杀性的临床显著变化.
- 探索参与者对西辅助心理支持的定性感知.
主要方法:
- 一项开放性可行性研究,涉及10名成人女性参与者,符合DSM-5对AN或部分缓解 (pAN) 的标准.
- 参与者接受了一次25毫克的合成 псилоцибин剂量与心理支持相结合.
- 安全性和耐受性通过AEs,心电图,实验室测试,生命体征和自杀性评估进行评估.
主要成果:
- 发现在psilocybin治疗是安全的和可以容忍的,所有的AE都是轻微的和短暂的.
- 没有观察到心电图,生命体征或自杀倾向的临床显著变化.
- 两名参与者经历了无症状低血糖症,在24小时内消失;没有其他显著的实验室异常.
结论:
- 对于女性神经性厌食症患者来说,psilocybin治疗是一种安全,耐受和可接受的干预措施.
- 这些发现支持进一步调查西作为一种潜在的新疗法.
- 这项研究强调了迷幻药辅助治疗在解决与AN治疗参与相关的挑战方面的潜力.
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