多目标治疗在患有狼性炎的儿童中的有效性和安全性
Xiaohong Zheng1, Xiaojun Ouyang1, Cheng Cheng1
1Department of Pediatric Nephrology and Rheumatology, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Pediatric research
|July 24, 2023
概括
使用葡萄糖皮质类药物,mycophenolate mofetil和tacrolimus的多目标疗法在治疗儿科狼性炎 (LN) 中显示出有效性. 这种方法为患有耐火或复杂LN病例的儿童提供了安全有效的选择.
科学领域:
- 儿科脏病学 儿科脏病学
- 免疫学 免疫学 免疫学
- 类风湿病学 类风湿病学
背景情况:
- 狼性炎 (LN) 是儿童系统性红斑狼的严重并发症.
- 对于某些LN亚型或耐火病例,标准治疗可能不足.
- 需要新的治疗策略来改善儿科LN的结果.
研究的目的:
- 评估多目标治疗方案在被诊断为狼性炎的儿童中的疗效和安全性.
- 评估治疗对疾病活动的临床和血清学标志物的影响.
- 为了确定该方案适用于耐火或复杂的LN病例的适用性.
主要方法:
- 从2009年到2021年,对36名患有狼性炎的儿科患者进行了回顾性分析.
- 多目标诱导或再诱导疗法包括葡萄糖皮质类药物,甲酸莫菲蒂尔 (MMF) 和塔克罗利斯.
- 收集和分析了临床,病理和实验室参数的数据.
主要成果:
- 观察到24小时尿蛋白,抗dsDNA抗体和SLE疾病活性指数的显著减少.
- 治疗后发现了白蛋白和补充3水平的增加.
- 超过90%的患者在6个月内实现了部分或完全缓解;报告的副作用很小.
结论:
- 多目标疗法是儿科狼性炎的有效治疗方法,特别是在耐火性病例或联合增殖性和膜性LN病例中.
- 该疗法表现出了有利的安全性概况,不常见,可控的不良反应.
- 这种治疗方法为具有挑战性的儿科LN病例提供了有希望的替代方案.
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