复原皮质肉瘤中的新辅助化疗:一项全国性队列研究
Gabriella N Tortorello1, Eric H Li2, Cimarron E Sharon3
1Division of Endocrine and Oncologic Surgery, Department of Surgery, Hospital of the University of Pennsylvania, Philadelphia, PA, USA. Gabriella.tortorello@pennmedicine.upenn.edu.
Annals of surgical oncology
|July 24, 2023
概括
新辅助化疗 (NCT) 没有改善经过手术的瘤患者的整体存活率. 这项对高度乳腺髓肉瘤和非分化脂肉瘤的回顾性分析表明,NCT没有提供生存益处.
科学领域:
- 在瘤学瘤学.
- 手术瘤学手术瘤学
- 医学瘤学 医学瘤学
背景情况:
- 逆肌肉瘤 (RPS) 的管理具有挑战性,手术是主要治疗方法.
- 新辅助性辐射没有改善生存率,新辅助性化疗 (NCT) 的疗效正在调查中.
研究的目的:
- 评估新辅助化疗 (NCT) 对切除后皮质脂肪瘤 (LMS) 或分离脂肪瘤 (DDLS) 的患者整体存活期 (OS) 的影响.
主要方法:
- 国家癌症数据库 (2006-2019) 对高度RPS (LMS或DDLS) 患者的回顾性分析.
- 单变量和多变量逻辑回归确定了NCT的预测因素.
- 卡普兰-梅尔和考克斯的比例危险模型评估了NCT和非NCT组之间的5年OS差异,并与倾向性匹配.
主要成果:
- 在2656名患者中,6%接受了NCT. 接受NCT的患者年轻,患LMS的可能性更高.
- 在卡普兰-梅尔分析中,在NCT和非NCT组之间没有观察到5年OS的显著差异 (57.3%与52.8%,p=0.38).
- 倾向匹配和组织学分层也显示,NCT对LMS或DDLS都没有OS益处.
结论:
- 新辅助性化疗似乎没有改善患者的整体存活率 进行手术切除的患者为LMS或DDLS.
- 来自STRASS2试验的前性数据是必要的,以证实这些回顾性发现.
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