在多民族队列研究中,亚托皮性过敏症和前列腺癌风险和生存率
Anqi Wang1, Peggy Wan1, James R Hebert2
1Center for Genetic Epidemiology, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, US.
British journal of cancer
|July 24, 2023
概括
亚托皮性过敏状况 (AAC) 没有影响前列腺癌 (PCa) 发病率,但与较低的PCa死亡率有关. 这种反向关联在不同人群中是一致的,这表明AAC可能会影响瘤进展.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 流行病学 流行病学
背景情况:
- 之前关于阿托皮性过敏症 (AACs) 和前列腺癌 (PCa) 风险的研究得出了不确定的结果.
- 很少有研究在不同的种族和民族群体中探索了这种关系.
研究的目的:
- 调查自我报告的AAC与前列腺癌 (PCa) 发病率和死亡率之间的关联.
- 检查这些协会跨越各种种族和民族群体.
主要方法:
- 从多民族队列研究中对74714名年龄≥45岁的男性进行分析.
- 使用多变量考克斯回归来估计AAC状态和PCa结果的危险比率 (HRs) 和95%置信区间 (CI).
- 调整了潜在的混因素,如PSA查,并考虑了饮食炎症指数.
主要成果:
- 患有AAC的病史与发生PCa的风险增加无关 (HR=0.98).
- AAC与PCa死亡率 (HR=0.79) 和PCa特定死亡率 (HR=0.75) 相反地显著相关.
- 这种与死亡率的反向关联在所有种族/族群中都是一致的.
结论:
- 亚托皮性过敏状况 (AACs) 与前列腺癌 (PCa) 发病率无关.
- AACs与PCa死亡率呈反向关联,这表明它可能在减少瘤进展方面发挥作用.
- 需要进一步的研究来阐明这种关联的潜在机制.
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