使用社会互动模型对子皮肤损伤的遗传分析
Natália Galoro Leite1, Egbert Knol2, Shogo Tsuruta3
1Department of Animal and Dairy Science, University of Georgia, Athens, GA, 30602, USA. nataliagaloro@uga.edu.
Genetics, selection, evolution : GSE
|July 24, 2023
概括
猪的结合性皮肤损伤是遗传的,并受到社会遗传的影响. 基因选择和基因组信息提高了育种价值,提高了动物福利和生产效率.
科学领域:
- 动物遗传学动物遗传学
- 动物育种 动物育种
- 动物福利 动物福利
背景情况:
- 皮肤损伤是猪在经济上具有重要意义的特征,它是由战斗和咬伤等社会互动引起的.
- 目前的育种策略侧重于直接的遗传效应,可能忽视对福利至关重要的社会遗传效应.
- 考虑到直接和社会遗传影响的组合选择可能会增强遗传收益并减轻竞争行为中的负面反应.
研究的目的:
- 估计结合性皮肤损伤 (CSD) 的方差成分,有或没有社会遗传效应.
- 评估基因组信息对CSD估计育种值的准确性,偏差和分散性的影响.
- 通过使用经典和社会相互作用模型,对CSD进行单步全基因组关联研究 (ssGWAS).
主要方法:
- 用动物模型估计中央证券交易所的差异成分.
- 基因组信息在育种价值预测中的应用.
- 单步全基因组关联研究 (ssGWAS) 以确定CSD的遗传标记.
主要成果:
- 中枢神经疾病是遗传的,并受到社会遗传效应的显著影响,社会相互作用模型将遗传变异增加了三倍.
- 基因组信息至少提高了21.2%的育种价值的预测准确性,并减少了偏差和分散.
- ssGWAS没有检测到与CSD直接或社会遗传影响相关的显著单核酸多态,表明多基因结构.
结论:
- 考虑到社会遗传效应,针对CSD的遗传选择对于长期改善动物福利至关重要.
- 社会互动模型增强了CSD的遗传改进潜力.
- 基因组信息提高了CSD估计的繁殖值的准确性和可靠性,尽管存在剩余偏差.
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