系统性免疫炎症指数和美国成年人的低肌肉质量之间的关联:一个横截面研究
Lin Shi1, Liang Zhang2, Dan Zhang3
1Department of Gastroenterology, Xuzhou Central Hospital, Xuzhou Clinical School of Xuzhou Medical University, Xuzhou, Jiangsu, China.
BMC public health
|July 24, 2023
概括
系统性免疫炎症指数 (SII) 的升高与低肌肉质量的更高风险有关. 这一发现突显了炎症和肌肉健康之间的联系,表明抗炎疗法的潜在益处.
科学领域:
- 老年学是指老年学的学科.
- 免疫学 免疫学 免疫学
- 营养科学 营养科学
背景情况:
- 慢性炎症越来越多地与肌肉质量减少有关.
- 系统性免疫炎症指数 (SII) 是系统性炎症的新标志物.
- 了解炎症和肌肉质量之间的联系对于公共健康至关重要.
研究的目的:
- 为了研究系统性免疫炎症指数 (SII) 和低肌肉质量之间的关系.
- 确定SII是否可以作为低肌肉质量的预测指标.
- 在一个庞大而多样化的群体中探索协会.
主要方法:
- 使用国家健康和营养检查调查数据 (2011-2018) 进行的横截面研究.
- 系统性免疫炎症指数 (SII) 计算为 (血小板数 × 中性粒细胞数) / 淋巴细胞数.
- 根据尾骨肌肉指数定义的低肌肉质量;使用多变量逻辑回归和光滑曲线拟合进行分析.
主要成果:
- 分析包括10,367名个人 (平均年龄39.39岁,49.17%是男性).
- 低肌肉质量的患病率为8.77%;在SII和低肌肉质量之间观察到近线性关系.
- 较高的SII四分位数与较低肌肉质量的可能性增加相关 (Q4 OR:1.28,95% CI:1.16-1.40).
结论:
- 增加的SII水平与较低肌肉质量的更高风险显著相关.
- 这项研究增强了对炎症和肌肉健康之间的相互作用的理解.
- 抗炎症策略可能有助于管理或预防低肌肉质量.
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