在狗的短期普得尼松和普得尼索隆的感知和使用
Margaret Gober1, Andrew Hillier2
1Zoetis LLC, 10 Sylvan Way, Parsippany, NJ, 07054, USA. Margaret.Gober@zoetis.com.
BMC veterinary research
|July 24, 2023
概括
短期使用皮质类固醇可显著增加狗的行为副作用,如增加排尿和口渴,影响到14日几乎所有的狗. 尽管业主满意度很高,但许多人会选择更少不良事件的替代品.
科学领域:
- 兽医医学 兽医医学 兽医医学
- 药理学 药理学是指药理学的学科.
- 动物行为 动物行为
背景情况:
- 皮质类固醇通常由兽医处方,其副作用概况被认为较低.
- 皮质类固醇副作用的低估可能是由于报告的发病率低 (<5%) 和一般兽医的舒适性.
- 这可能会导致对这些药物对物及其主人的影响的自满.
研究的目的:
- 为了评估所有者报告的副作用和对接受口服前尼松或前尼索隆抗炎剂量长达14天的狗的看法.
- 为了测试假设,狗在第14天经历的副作用比目前文献中报道的高得多.
主要方法:
- 一项涉及45只狗的临床研究最初招募了.
- 业主服用口服普雷迪尼松或普雷迪尼索隆,长达14天.
- 在特定的研究点收集了业主报告的行为变化.
主要成果:
- 到第5天,74%的老板报告了行为变化,包括增加排尿 (多尿症),口渴 (多尿症),食欲 (多) 和发声.
- 到第14天,90%的车主报告至少发生了一种行为变化,多尿症和多多是最常见的.
- 61%的业主注意到水消耗增加,三分之一的业主报告说,以前的大陆狗的尿路事故.
结论:
- 短期的抗炎剂量普雷尼松/普雷尼索隆显著改变狗的行为,90%的狗在第14天经历了变化.
- 无论剂量或治疗方案如何,都观察到不良事件.
- 尽管高效率和业主满意度高 (4.5/5),但70%的业主会选择更便宜,副作用更少的治疗方法.
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