同时的高强度间歇训练和益生菌补充剂通过增加卵巢切除的老鼠的胰岛素敏感性来改善关联记忆
Zeinab Bayat1,2, Arsalan Damirchi1, Meysam Hasannejad-Bibalan3
1Department of exercise physiology, Faculty of Physical Education &sport sciences, The University of Guilan, Rasht, Iran.
BMC complementary medicine and therapies
|July 24, 2023
概括
高强度间歇训练 (HIIT) 与益生菌补充剂相结合,改善了代谢综合征的老鼠的关联记忆. 这种干预也提高了胰岛素敏感性和皮内克水平,这表明了潜在的治疗策略.
科学领域:
- 内分泌学和新陈代谢学
- 神经科学是一个神经科学.
- 微生物学 微生物学
背景情况:
- 代谢综合征 (MetS) 对绝经后妇女的心血管和认知健康构成风险.
- 饮食和运动是管理MetS进展的关键策略.
- 在老鼠的卵巢切除诱导的MetS作为研究人类条件的模型.
研究的目的:
- 为了研究高强度间歇训练 (HIIT) 和益生菌补充剂在MetS的老鼠模型中对关联记忆的联合影响.
- 评估这些干预措施对代谢标志物和荷尔蒙水平的影响.
主要方法:
- 32只经过卵巢切除的Wistar大鼠被分为四组:控制,运动 (HIIT),益生菌和联合运动-益生菌.
- 干预持续了8周,随后使用被动回避测试进行记忆评估.
- 测量了腺素,胰岛素和葡萄糖的血清水平.
主要成果:
- 与对照组相比,HIIT和益生菌组组合显示出较好的关联记忆.
- 在综合干预组中观察到血清阿迪波涅丁的显著增加和葡萄糖,胰岛素和HOMA-IR的减少.
- 这些代谢改善与增强的记忆保留有关.
结论:
- 结合HIIT和益生菌补充剂有效地改善了卵巢切除诱导的MetS大鼠模型中的关联记忆.
- 这些益处部分通过改善胰岛素敏感性和阿迪波内克水平来调解.
- 这表明了与MetS相关的认知缺陷的潜在治疗方法.
更多相关视频
06:28A Chronic High-Intensity Interval Training and Diet-Induced Obesity Model to Maximize Exercise Effort and Induce Physiologic Changes in Rats
Published on: April 28, 2023
875
06:13Author Spotlight: Exploring the Impact of Reduced Resistance Exercise Volume on Metabolic Health
Published on: December 1, 2023
1.1K
相关概念视频
Probiotics
Probiotics are live, non-pathogenic microorganisms that confer health benefits by modulating the gut microbiota. The human gastrointestinal tract harbors a complex microbial ecosystem, and the balance of this microbiota is crucial for digestive and systemic health. Among the most extensively studied and utilized probiotics are species formerly classified within the genera Lactobacillus and Bifidobacterium. These organisms not only naturally colonize the human gut but are also consumed through...
Microbiota Modulation by Antibiotics
Antibiotics have revolutionized modern medicine by saving countless lives from bacterial infections. However, their widespread use has inadvertently harmed the delicate balance of the human gut microbiota. The gut microbiota, a complex community of bacteria, archaea, viruses, and fungi, plays a vital role in regulating metabolism, immune responses, and maintaining intestinal health. Antibiotics, especially broad-spectrum types, disrupt this ecosystem by eradicating both harmful and beneficial...
