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生物活性水凝用于修复脊髓损伤的最新进展:材料设计,生物功能调节和应用

Zhengang Sun^1,2,3, Danzhu Zhu⁴, Hong Zhao²

¹Department of Spinal Surgery, Affiliated Hospital of Qingdao University, Qingdao, 266071, People's Republic of China.

Journal of nanobiotechnology

|July 24, 2023

概括

生物活性水凝为脊髓损伤 (SCI) 修复提供了有希望的解决方案. 本综述详细介绍了材料设计和功能调节策略,以增强水凝特性,改善SCI治疗结果.

科学领域:

生物材料科学生物材料科学
再生医学是一种再生医学.
纳米技术纳米技术

背景情况:

功能性水凝在脊髓损伤 (SCI) 修复方面具有独特的特性.
现有的审查缺乏专注于SCI的特定材料设计和功能调节策略.
生物活性水凝对于提高SCI修复性能至关重要.

研究的目的:

审查生物活性水凝设计和SCI修复功能调节的最新进展.
突出材料设计和水凝的生物功能化策略.
为了证明这些进步如何促进SCI修复效率.

主要方法:

制造包含生物成分 (DNA,蛋白质,,多糖,生物聚合物) 的生物活性水凝.
使用药物,生长因子,聚合物,纳米颗粒和纳米材料 (1D和2D) 的水凝的功能调节.
对传递细胞生物相容性,自我愈合,抗菌活性,可注射性,生物粘附性和生物降解性等特性方法的审查.

主要成果:

生物活性水凝可以与各种生物成分进行工程设计,以实现所需的功能.
用各种药物的功能调节可以提高SCI治疗的水凝性能.
材料科学和纳米技术的整合为生物活性水凝开发提供了新的方法.

结论:

生物活性水凝代表了SCI修复策略的重大进步.
量身定制的材料设计和功能调节是最大限度地发挥治疗潜力的关键.
这次审查将材料科学与生物医学联系起来,激发了SCI治疗中水凝的未来临床应用.

关键词:

生物活性生物活性生物医学工程生物医学工程功能性规范功能性规范功能性规范水凝是一种水凝.脊髓损伤导致的脊髓损伤

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