相关实验视频

Updated: Jul 22, 2025

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development

Published on: June 24, 2020

找出感染性早产的炎症生物标志物的优先级和集群:系统性审查

Jiayi Li¹, Jianrong Ge¹, Na Ran¹

¹School of Medicine, Shaoxing University, Shaoxing, Zhejiang, 312000, China.

Journal of inflammation (London, England)

|July 24, 2023

概括

预测传染性早产 (PTB) 是至关重要的. 这项研究确定了关键的炎症生物标志物和集群,如sTNFR2和TNF/NGF,以根据妊娠年龄准确预测PTB.

科学领域:

产科和妇科产科和妇科
免疫学免疫学免疫学
围产儿医学围产儿医学

背景情况:

传染性早产 (PTB) 是围产死亡的主要原因.
缺乏准确的妊娠周特定生物标志物来预测传染性PTB.
免疫失衡通常伴随着传染性PTB,需要对炎症标志物的研究.

研究的目的:

系统地识别和优先考虑炎症生物标志物用于传染性PTB预测.
发现新的炎症生物标志物集群,用于预测传染性PTB.
根据妊娠年龄建立可靠的传染性PTB预测指标.

主要方法:

对有关炎症集群和传染性PTB的研究进行系统审查和网络元分析.
使用了人口,干预,比较,结果和研究设计 (PICOS) 框架.
遵循系统审查和元分析 (PRISMA) 准则的首选报告项目.

主要成果:

感染性PTB预测的炎症因素的优先考虑:可溶性瘤缩因子受体2 (sTNFR2) >瘤缩因子α (TNFα) >互白素-10 (IL-10) >互白素-6 (IL-6) >C反应蛋白 (CRP) >互白素-1β (IL-1β).
确定了潜在的预测生物标志物集群:CRP/IL-1β/IL-6 (怀孕27-34周) 和TNF/NGF家族 (怀孕25-33周).
证明母亲的炎症集群可以预测特定妊娠周的传染性PTB.

结论:

建立了一个清晰的炎症生物标志物等级来预测传染性PTB.
提供了对母体炎症集群在预测传染性PTB的疗效的证据.
强调在精确的妊娠年龄考虑多种炎症因素对于PTB预测的重要性.

关键词:

生物标志物生物标志物炎症因子是一种炎症因子.母亲的血液来自母亲的血液.过早分娩过早分娩是什么确定优先级确定优先级

更多相关视频

A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis

A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis

Published on: August 12, 2020

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats

Published on: November 20, 2015

相关概念视频

Factors Affecting the Risk of Infection

Factors Affecting the Risk of Infection

The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...