人类适应和多样化在Microsporum canis复杂的复杂
Xin Zhou1,2, Sarah A Ahmed1,3, Chao Tang1
1Center of Expertise in Mycology of Radboud University Medical Center, Canisius Wilhelmina Hospital, Nijmegen, The Netherlands.
IMA fungus
|July 24, 2023
概括
Microsporum canis复合体是物和人类真菌感染的常见原因,显示出进化的适应性. 分子和物理特征表明,动物友好的M. canis演变为人类友好的物种.
科学领域:
- 菌类学 菌类学是指菌类学.
- 进化生物学 进化生物学
- 动物传播疾病 动物传播疾病
背景情况:
- 麦克罗斯波 (Microsporum canis) 综合体包括动物爱好者M. canis和人类爱好者M. audouinii和M. ferrugineum.
- 这些物种是重要的动物性传染病原体,在全球范围内在猫和人类中引起皮肤植物病.
研究的目的:
- 为了阐明微体内进化关系,canis复杂.
- 研究宿主从动物性转向人类性真菌物种的转移过程.
主要方法:
- 遗传学分析和人口结构分析.
- 多种类的凝聚分析,MAT idiomorph分布和性交交叉.
- 宏观形态学,物理化学性质和酶活性 (脂酶,脂溶解,尿素,DNase).
主要成果:
- 在该综合体内确定了12种基因型.
- M. canis 具有 MAT1-1,而人类性物种具有 MAT1-2. 在M. canis和M. audouinii之间发生了性繁殖.
- 动物友好的M. canis比人类友好的菌株表现出更高的生长率和酶活性 (脂酶,脂溶解,尿素);M. ferrugineum具有更高的DNase活性.
结论:
- 物理化学性质和分子数据支持动物友好的M. canis适应人类友好的物种.
- 而M. audouinii似乎是这个进化过程中的中间物种.
- 最佳生长发生在28°C,而22°C有利于宏菌的发展.
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