血清铁和肝转氨酶之间的关联基于大量的成年女性人口
Andong He1, Zhuoping Zhou1, Lili Huang2
1Department of Obstetrics and Gynecology, The First Affiliated Hospital of Jinan University, No. 613, Huangpu Road West, Tianhe District, Guangzhou, 510630, Guangdong, China.
Journal of health, population, and nutrition
|July 24, 2023
概括
血清铁与成年女性的肝酶氨酸转移酶 (ALT) 和酸氨酸转移酶 (AST) 有积极的联系. 这表明血清铁可能作为肝功能生物标志物.
科学领域:
- 生物化学 生物化学
- 临床医学 临床医学
- 营养科学 营养科学
背景情况:
- 铁在各种疾病中的作用正在调查中.
- 成年女性血清铁与肝损伤之间的特定关联需要进一步澄清.
研究的目的:
- 研究血清铁含量与肝损伤标志物,特别是ALT和AST之间的关系.
- 在一大群成年女性中探索这些关联.
主要方法:
- 利用了来自国家健康和营养检查调查的19,185名成年女性的数据.
- 使用加权多变量回归,子组和值效应分析.
- 进行敏感性分析以确认发现的可靠性.
主要成果:
- 在血清铁和ALT和AST之间观察到显著的,独立的和正相关性.
- 这些关联在不同年龄组和种族之间有所不同.
- 这种关系显示出非线性模式,在所有女性和非孕妇中确定了ALT的转折点.
- 在对共变量进行调整后,在非孕妇中持续存在积极的关联,并排除了患有并发症的个体,但在孕妇中没有.
结论:
- 血清铁与肝转氨酶 (ALT和AST) 有积极的关联.
- 血清铁可以作为评估成年女性肝功能的潜在生物标志物.
- 这些发现强调了在肝脏健康评估中考虑铁状况的重要性.
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