相关实验视频
Updated: Jul 22, 2025
05:48
Rapid Generation of Amyloid from Native Proteins In vitro
Published on: December 5, 2013
6.2K
再发性SARS-CoV-2感染后的胃肠道AA氨基化症:一个病例报告
Hyung-Min Park1, Seon-Young Park2, Soo Jin Na Choi3
1Division of Gastroenterology, Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Korea.
Yonsei medical journal
|July 25, 2023
概括
严重急性呼吸系统综合征冠状病毒2 (SARS-CoV-2) 感染可能导致胃肠道AA氨基化症. 这项案例研究强调了一名移植患者,在SARS-CoV-2感染和再感染后患上了GI AA粉样化症.
科学领域:
- 胃肠病学 胃肠病学
- 传染性疾病 传染性疾病
- 腎臟病學 (nephrology) 是一種醫學專業.
背景情况:
- 严重急性呼吸道综合征冠状病毒2 (SARS-CoV-2) 感染与血清粉样蛋白A蛋白水平升高有关,可能导致系统性AA粉样蛋白症.
- 在SARS-CoV-2感染后的AA氨基粉症中,胃肠道 (GI) 的参与是一种罕见但严重的并发症.
研究的目的:
- 在 SARS-CoV-2 感染后,在脏移植接受者中报告胃肠道 AA 粉症病例.
- 为了说明这种罕见并发症的临床表现,诊断过程和管理.
主要方法:
- 一个75岁的男性脏移植接受者的病例报告,患上腹部上部疼痛,有SARS-CoV-2感染史.
- 诊断程序包括食管胃管腺镜和结肠镜与活检.
- 组织学检查证实了胃肠道中粉样蛋白A的存在.
主要成果:
- 患者在移植后6周出现持续的腹痛和血,在SARS-CoV-2感染和随后的再感染后.
- 内镜检查发现了多种胃和结肠.
- 组织病理学证实了AA粉样蛋白沉积.
- 保守的管理和抗病毒疗法 (remdesivir) 导致临床改善和愈.
结论:
- 胃肠道AA Amyloidosis可能是SARS-CoV-2感染的亚急性并发症,特别是在免疫功能低下的患者中.
- 早期诊断和适当的治疗对于改善患者的治疗结果至关重要.
- 这一案例强调了在有相关传染病史和胃肠道症状的移植受体中考虑GI粉症的重要性.
相关概念视频
03:03Amyloid Fibrils
9.6K
Amyloid fibrils are aggregates of misfolded proteins. Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils.
Amyloid deposits were observed as early as 1639 in the liver and the spleen. In 1854, Rudolph Virchow performed iodine staining,...
Amyloid deposits were observed as early as 1639 in the liver and the spleen. In 1854, Rudolph Virchow performed iodine staining,...
9.6K
01:17Gastritis-II: Pathophysiology
379
Gastritis is marked by disruption of the mucosal barrier that usually protects the stomach tissue from digestive juices and manifests in acute and chronic forms.
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
379
01:50What is Monogastric Digestion?
71.6K
The human body contains a monogastric digestive system. In a monogastric digestive system, the stomach only contains one chamber in which it digests food. Several other animal species also have monogastric digestive systems, including pigs, horses, dogs, and birds. This chapter, however, focuses on the human digestive system.
71.6K
01:30Acute Pancreatitis II: Clinical Manifestations and Management
150
Acute pancreatitis presents a complex medical emergency characterized by rapid onset inflammation of the pancreas, demanding timely diagnosis and management to prevent complications. The condition primarily manifests through severe upper abdominal pain that often radiates to the back. This pain intensifies following the consumption of fatty foods. Accompanying symptoms such as nausea, vomiting, abdominal distention, fever, dyspnea, cyanosis, and jaundice can vary in intensity but significantly...
150
01:27Acute Pancreatitis I: Introduction
408
Pancreatitis is inflammation of the pancreas, an organ located behind the stomach. It can be either acute or chronic.
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
408
01:20Myasthenia Gravis: Overview and Treatment
1.6K
Myasthenia gravis is a neuromuscular transmission disorder characterized by weakness and increased fatigability of skeletal muscles. It is an autoimmune disease affecting approximately one in 2000 people, where antibodies against the α1 subunit of nicotinic acetylcholine receptors are produced.
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which...
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which...
1.6K