益生菌在儿科亚托邦性皮肤炎中的有效性:系统性审查和元分析
Xiali Xue1, Xinwei Yang1, Xiubo Shi2
1School of Sports Medicine and Health, Chengdu Sport University, Chengdu, China.
Clinical and translational allergy
|July 25, 2023
概括
益生菌对儿童的亚托皮炎 (AD) 有积极影响,特别是单菌株治疗. 然而,需要更多高质量的研究来证实这些发现用于儿科阿尔茨海默病的治疗.
科学领域:
- 儿科皮肤病学 儿科皮肤病学
- 微生物组研究 微生物组研究
- 临床试验 临床试验
背景情况:
- 亚托邦性皮肤炎 (AD) 是一种常见的儿童皮肤疾病.
- 益生菌正在被研究作为一种潜在的治疗阿尔茨海默病.
- 这项研究评估了益生菌在儿科AD的疗效.
研究的目的:
- 为了评估益生菌干预措施在改善SCORAD (无氧性皮肤炎严重程度) 值的有效性,在患有AD的儿童中.
- 系统地审查随机对照试验 (RCT),将益生菌治疗与儿科AD的安慰剂进行比较.
主要方法:
- 在多个数据库 (PubMed,Embase,Scopus等) 的系统文献搜索. 在2010年1月至2023年1月期间发表的RCT.
- 包括专注于患有AD的儿科患者的研究,评估SCORAD值.
- 偏差风险和证据确定性使用Cochrane ROB 2.0.0进行了评估.
主要成果:
- 对9项涉及1000名患者的RCT的分析显示,益生菌和对照组之间的二分结果没有显著差异 (p=0.23).
- 对连续变量的分析显示,随着益生菌治疗,SCORAD值显著改善 (p=0.002).
- 亚组分析表明,年龄,治疗持续时间或益生菌物种对SCORAD值没有统计学上显著的影响.
结论:
- 目前的证据表明,益生菌对儿科阿尔茨海默病的影响有限但积极,特别是单菌株配方.
- 需要高质量的研究来验证这些发现,因为包含的研究数量和质量的限制.
相关概念视频
01:30Development of Human Microbiota
The human microbiota begins developing at birth and undergoes continual change as we age. Infancy marks a critical period of microbial sensitivity, offering a “window of opportunity” during which beneficial microbes help mature the immune system. By age three, children typically develop a more stable and diverse microbial community. Newborns acquire microbes from their immediate environment; vaginal delivery favors maternal vaginal microbes, while cesarean births favor microbes from the skin...
01:27The Skin Microbiota
The human skin serves as a complex ecosystem inhabited by a diverse community of microorganisms, including bacteria, fungi, and viruses. This microbiome plays a critical role in maintaining skin health and defending against pathogenic invaders. The composition of microbial communities varies significantly across different regions of the body, influenced primarily by the local levels of moisture and sebum.Regional Variation in Skin MicrobiotaCutibacterium acnes predominantly colonizes sebaceous...
01:21Microbiota Modulation by Antibiotics
Antibiotics have revolutionized modern medicine by saving countless lives from bacterial infections. However, their widespread use has inadvertently harmed the delicate balance of the human gut microbiota. The gut microbiota, a complex community of bacteria, archaea, viruses, and fungi, plays a vital role in regulating metabolism, immune responses, and maintaining intestinal health. Antibiotics, especially broad-spectrum types, disrupt this ecosystem by eradicating both harmful and beneficial...
01:29Staphylococcal Skin Infections
Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
01:27Acne Infection
Acne is a multifactorial skin condition primarily affecting adolescents and young adults, with a global prevalence estimated to exceed 75% in this demographic. The condition is characterized by the formation of comedones (blackheads and whiteheads), papules, pustules, nodules, and, in severe cases, cysts, particularly in areas rich in sebaceous glands such as the face, neck, chest, and back. The pathogenesis involves increased sebum production, follicular hyperkeratinization, colonization by...