肠道本能:肠道微生物组的性别差异与大鼠在母亲分离后的青少年 nociception 的变化有关
Sabrina Salberg1, Matthew Macowan2, Glenn R Yamakawa1
1Department of Neuroscience, Monash University, Melbourne, Victoria, Australia.
Developmental neurobiology
|July 25, 2023
概括
青少年慢性疼痛显示了肠道微生物组合的性别差异,特别是在不良童年经历 (ACE) 和受伤后. 这些变化可能会解释男性和女性的不同疼痛结果.
科学领域:
- 神经科学是一个神经科学.
- 微生物学 微生物学
- 疼痛研究 疼痛研究
背景情况:
- 青少年慢性疼痛是一个日益严重的公共卫生问题,对其原因的了解有限.
- 慢性疼痛的患病率是两性变异的,女性的患病率是男性的两倍.
- 临床前研究主要使用男性受试者,造成女性疼痛机制的知识差距.
研究的目的:
- 调查肠道微生物组组成和功能的性别依赖的变化.
- 检查童年不良经历 (ACE) 和急性损伤对肠道微生物群的影响.
- 探索肠道微生物组变化,性别和慢性疼痛发展之间的关系.
主要方法:
- 雄性和雌性Sprague Dawley大鼠幼经历了母体分离 (MS) 或没有压力.
- 动物进一步被分配到虚假,轻度创伤性脑损伤 (mTBI) 或手术条件.
- 使用弗雷测试来评估机械性 nociception,并通过16S rRNA测序分析便样本.
主要成果:
- 与mTBI和假组相比,手术诱导疼痛敏感度增加,与肠道微生物组变化相关.
- 在肠道微生物组组成中观察到显著的性别差异.
- 母亲分居加剧了肠道微生物组的性别差异.
结论:
- 初步证据表明,性别差异和ACE诱导的细菌组成变化有助于各种慢性疼痛结果.
- 肠道微生物组和脑-肠-免疫轴可能在性别特定的慢性疼痛发展中发挥作用.
- 需要进一步的研究来阐明依赖性慢性疼痛的机制和肠道微生物组的作用.
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