根据克拉里胺素耐药性的根除,针对杆菌的7天量身定制治疗的有效性
June Hwa Bae1, Hyeong Ho Jo1, Joong Goo Kwon1
1Department of Internal Medicine, Daegu Catholic University School of Medicine, Daegu, Korea.
概括
量身定制的7天疗法有效地消灭了Helicobacter pylori (H. pylori),即使具有高克拉胺素 (CAM) 耐药性. 这种方法为H. pylori治疗成功提供了一个可行的策略.
科学领域:
- 胃肠病学 胃肠病学
- 传染性疾病 传染性疾病
- 微生物学 微生物学
背景情况:
- 在Helicobacter pylori (H. pylori) 中增加克拉里素 (CAM) 耐药性降低了标准三重疗法根除率.
- 高频率的CAM耐药性 (34.5%) 需要替代治疗策略.
研究的目的:
- 根据CAM耐药性测试,评估针对H. pylori根除的7天量身定制治疗的疗效.
- 为了确定量身定制的治疗是否是一个有用的策略,尽管CAM耐药性很高.
主要方法:
- 在2017年1月至2022年5月期间,共招募了481名H. pylori患者.
- 患有CAM耐药性的患者接受了为期7天的基于木的四重疗法;没有接受的患者接受了为期7天的标准三重疗法.
- 通过使用基于双启动寡核酸的多重PCR识别了CAM耐药性.
主要成果:
- 总的H. pylori根除率为89.4% (按协议分析).
- 根除率在CAM耐药 (88.8%) 和CAM敏感 (89.7%) 组之间是可比的.
- 对治疗意图的分析显示,对CAM耐药组的根除率为81.3%,对CAM敏感组的根除率为77.5%.
结论:
- 7天的量身定制疗法实现了高的H. pylori根除率 (89.4%),尽管存在显著的CAM耐药性.
- 基于CAM耐药性的量身定制治疗是H. pylori根除的可接受和有效的治疗策略.
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