韩国红人参缓解炎症并调节由伪型SARS-CoV-2引起的免疫反应
Ki Woong Kwon1, Ji Won Kim1, Seokoh Moon1
1Department of Integrative Biotechnology, Sungkyunkwan University, 2066 Seobu-ro, Suwon 16419, Republic of Korea.
The American journal of Chinese medicine
|July 25, 2023
概括
韩国红人参水提取物 (KRG-WE) 通过减少肺炎并使小鼠模型中的免疫反应正常化,显示出对SARS-CoV-2的治疗潜力.
科学领域:
- 免疫学 免疫学 免疫学
- 药理学 药理学是指药理学的学科.
- 病毒学 病毒学
背景情况:
- 有限的研究存在于韩国红人参 (KRG) 对SARS-CoV-2的疗效.
- 克罗地亚黄糖证明了对病毒感染和肺炎的已知益处.
研究的目的:
- 在伪型SARS-CoV-2 (PSV) 诱导的肺损伤模型中研究KRG-水提取物 (KRG-WE) 的治疗效果.
- 评估KRG-WE对免疫细胞群和炎症通路的影响.
主要方法:
- KRG-WE被口服给人类血管酶转化酶2 (hACE2) 转基因小鼠六周.
- 通过鼻内注射感染PSV的小鼠,并在感染后7天使用PCR,西斑,流细胞计和ELISA分析了效果.
主要成果:
- KRG-WE显著抑制了PSV诱导的免疫球蛋白增加.
- 它抑制了膜巨细胞 (AMs),使其他免疫细胞正常化,并降低了病毒基因表达和炎症信号 (NF-κB).
- 此外,KRG-WE还使脏中的基因表达和蛋白质活性正常化,减少了肺损伤.
结论:
- 通过减少AM和炎症基因表达,KRG-WE表现出抗炎作用.
- 它使免疫反应正常化,并在PSV诱导的肺损伤模型中减轻肺损伤.
- KRG-WE显示了与SARS-CoV-2相关的肺损伤的治疗潜力.
相关概念视频
Inflammatory Response
2.1K
An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
2.1K
Inflammatory Response I: Vascular and Cellular
11.4K
The inflammatory response is the body's defense against infection, injury, or irritation from bacteria, trauma, toxins, or heat. Inflammation helps locate and destroy pathogens and remove damaged tissue elements to heal the body. During this initial phase, fluid, blood products, and nutrients migrate to the injured area, resulting in redness, heat, swelling, ache, and loss of function. Moreover, signs of systemic inflammation include fever, increased WBC count, malaise, anorexia, nausea,...
11.4K


