Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Evolutionary Relationships through Genome Comparisons02:54

Evolutionary Relationships through Genome Comparisons

5.8K
Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
5.8K
Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

13.6K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
13.6K
Modern Molecular Taxonomy01:29

Modern Molecular Taxonomy

52
Advancements in molecular biology have revolutionized the identification and characterization of bacteria, with multiple methods leveraging DNA sequencing for enhanced precision. As sequencing technologies improve and costs decline, these approaches are increasingly used in clinical, environmental, and evolutionary studies.Multilocus Sequence Typing (MLST) examines several housekeeping genes, essential chromosomal genes encoding cellular functions, to distinguish strains. Approximately...
52
Gene Evolution - Fast or Slow?02:05

Gene Evolution - Fast or Slow?

7.2K
The genomes of eukaryotes are punctuated by long stretches of sequence which do not code for proteins or RNAs. Although some of these regions do contain crucial regulatory sequences, the vast majority of this DNA serves no known function. Typically, these regions of the genome are the ones in which the fastest change, in evolutionary terms, is observed, because there is typically little to no selection pressure acting on these regions to preserve their sequences.
In contrast, regions which code...
7.2K
Genomics02:02

Genomics

36.5K
Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
36.5K
What is Population Genetics?01:25

What is Population Genetics?

58.2K
A population is composed of members of the same species that simultaneously live and interact in the same area. When individuals in a population breed, they pass down their genes to their offspring. Many of these genes are polymorphic, meaning that they occur in multiple variants. Such variations of a gene are referred to as alleles. The collective set of all the alleles within a population is known as the gene pool.
58.2K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Convergent digestive adaptation to resource limitation in an insular lizard across a microgeographic archipelago.

The Journal of animal ecology·2026
Same author

Phylogeny-aware comparative genomics of <i>Vibrio vulnificus</i> links genetic traits to pathogenicity.

mBio·2026
Same author

Orthologs of an essential orphan gene vary in their capacities for function and subcellular localization in Drosophila melanogaster.

Molecular biology and evolution·2026
Same author

Generalist phyllosphere taxa dominate microbial communities on macrophytes across a natural salinity gradient.

Environmental microbiome·2026
Same author

Warming and Change in Ocean Productivity Alter Phenology of an Expanding Loggerhead Population in Cabo Verde.

Animals : an open access journal from MDPI·2026
Same author

Nutritional adaptation in the marine to freshwater establishment process - how do diet and genotype shape phenotype?

The Journal of experimental biology·2026

相关实验视频

Updated: Jul 22, 2025

Heuristic Mining of Hierarchical Genotypes and Accessory Genome Loci in Bacterial Populations
08:03

Heuristic Mining of Hierarchical Genotypes and Accessory Genome Loci in Bacterial Populations

Published on: December 7, 2021

2.2K

起源问题:使用局部参考基因组改善了人口基因组学中的措施.

Doko-Miles J Thorburn1,2, Kostas Sagonas1,3, Mahesh Binzer-Panchal4

  • 1School of Biological and Chemical Sciences, Queen Mary University of London, London, UK.

Molecular ecology resources
|July 25, 2023
PubMed
概括

使用局部参考基因组可以提高人口基因组学中的映射效率和基因型准确性. 这减少了参考偏差,增加了对遗传适应和人口结构研究下游分析的信心.

关键词:
胃骨 (Gasterosteus aculeatus) 是一种有毒的动物.基因组组装组合的基因组.妇产遗传学 妇产遗传学人口基因组学 人口基因组学读取映射读取映射的情况参考基因组是指基因组中的基因.参考映射偏差是指参考映射的偏差.坚持背部的坚持背部的坚持

更多相关视频

Novel Sequence Discovery by Subtractive Genomics
09:40

Novel Sequence Discovery by Subtractive Genomics

Published on: January 25, 2019

8.7K
Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease
09:34

Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease

Published on: April 4, 2018

33.8K

相关实验视频

Last Updated: Jul 22, 2025

Heuristic Mining of Hierarchical Genotypes and Accessory Genome Loci in Bacterial Populations
08:03

Heuristic Mining of Hierarchical Genotypes and Accessory Genome Loci in Bacterial Populations

Published on: December 7, 2021

2.2K
Novel Sequence Discovery by Subtractive Genomics
09:40

Novel Sequence Discovery by Subtractive Genomics

Published on: January 25, 2019

8.7K
Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease
09:34

Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease

Published on: April 4, 2018

33.8K

科学领域:

  • 人口基因组学是人口的基因组学.
  • 遗传学 遗传学 是一个
  • 生物信息学是一种生物信息学.

背景情况:

  • 参考基因组对于分析人口级别的复序数据至关重要.
  • 当存在多个选择时,选择合适的参考基因组是具有挑战性的.
  • 参考偏差可能会影响人口基因组学分析的准确性.

研究的目的:

  • 为了比较在人口基因组学中使用局部与非局部参考基因组的影响.
  • 评估遗传距离如何影响下游分析,使用不同的参考基因组.
  • 评估人口基因组指标和表观遗传分析中的参考偏差.

主要方法:

  • 用两个参考基因组 (欧洲和北美) 来绘制60只三脊的基因组复序数据.
  • 分析了绘图效率,基因型准确性和人口基因组指标 (π,Tajima的D,FST).
  • 从SNP数据和DNA甲基化分析中研究了异常基因和功能.

主要成果:

  • 一个局部参考基因组显著提高了映射效率和基因型准确性.
  • 虽然基于SNP的指标显示了可比的分布,但基于窗口的统计数据根据参考确定了不同的异常基因.
  • 基因甲基化分析也显示了异常基因和功能中的参考依赖差异.

结论:

  • 使用局部参考基因组可以最大限度地减少参考偏差,从而使人口基因组分析更可靠.
  • 参考基因组的选择影响了与适应和人口结构相关的基因的识别.
  • 这些发现对于提高所有基于基因组的基因组研究的准确性和可靠性至关重要.