儿科过敏的发展模式
Stanislaw J Gabryszewski1, Jesse Dudley2, Di Shu2,3
1Division of Allergy and Immunology.
Pediatrics
|July 25, 2023
概括
儿科过敏模式揭示了亚托皮炎 (AD) 和喘的高发病率. 许多儿童经历了多种过敏状况,支持过敏从食物到呼吸道过敏的概念.
科学领域:
- 儿科过敏和免疫学
- 流行病学 流行病学
- 电子健康记录研究研究 电子健康记录
背景情况:
- 儿科过敏是一种严重的公共卫生问题,具有复杂的临床和流行病学模式.
- 了解儿童过敏疾病的进展和同时发生对于有效的管理和预防策略至关重要.
研究的目的:
- 描述儿科过敏的临床和流行病学模式.
- 用纵向数据分析儿童中各种过敏疾病的发病率,诊断年龄和并发症.
主要方法:
- 从1999年到2020年使用了多州EHR数据库 (通过协作电子报告进行比较有效性研究).
- 定义了一个218,485名儿童 (0-18岁) 的队列,至少有5年的观察期.
- 通过使用诊断代码和药物数据,确定了亚托皮性皮肤炎 (AD),免疫球蛋白E介导的食物过敏 (IgE-FA),喘,过敏性鼻炎 (AR) 和异性食道炎 (EoE).
主要成果:
- 喘 (20.1%) 和过敏性鼻炎 (19.7%) 的累积发病率最高,诊断的早期峰值年龄 (喘13个月,AR26个月).
- 亚托匹性皮肤炎的累积发病率很高 (10.3%),在4个月后诊断得非常早.
- 食物过敏,特别是花生 (1.9%) 和蛋 (0.8%),是后来诊断出来的. 很大一部分 (13.4%) 患有多种过敏症,呼吸道过敏和其他过敏性疾病之间常见的并发症.
结论:
- 来自不同美国儿科实践的纵向EHR数据为儿童过敏流行病学提供了详细的见解.
- 研究结果支持"过敏征程"现象,即儿童从阿托皮性皮肤炎等疾病发展为食物和呼吸道过敏.
- 在食物和呼吸道过敏中,伴随性疾病的高率强调了儿童过敏护理中需要综合管理方法的需要.
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