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治疗耐药抑郁症而没有迷幻效应的psilocybin:为期4周的研究方案,双盲,概念验证随机对照试验

Muhammad Ishrat Husain¹, Daniel M Blumberger², David J Castle³

¹Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Canada; and Department of Psychiatry, Temerty Faculty of Medicine, University of Toronto, Canada.

|July 25, 2023

概括

这项研究研究了将psilocybin与risperidone结合用于治疗严重抑郁症. 这项研究旨在评估在没有迷幻体验的情况下的可行性,耐受性和潜在的抗抑郁作用.

科学领域:

神经科学是一个神经科学.
精神病学是一个精神病学.
药理学药理学是指药理学的学科.

背景情况:

在重大抑郁症 (MDD) 和治疗耐药性抑郁症 (TRD) 中,psilocybin 显示出显著的抗抑郁作用.
西的作用是由2A (5-HT2A) 血清素受体激活的介导.
像RISPERIDONE这样的5-HT2A受体对手可能会阻断psilocybin的迷幻和潜在的治疗作用.

研究的目的:

确定在成年人中与TRD结合psilocybin与risperidone的可行性和耐受性.
为了确定瑞斯佩里能否阻断psilocybin的迷幻效应.
收集关于西与瑞斯佩里结合的抗抑郁药物的试点数据.

主要方法:

一个为期4周的,三臂,双模拟随机对照试验 (RCT).
60名患有TRD的成年人将随机分配到西 (25毫克) + 里斯佩里 (1毫克),西 (25毫克) +安慰剂或安慰剂 + 里斯佩里 (1毫克).
所有参与者都接受了12小时的手动化心理治疗;可行性,耐受性和安全性将被评估.

主要成果:

这项试验旨在进一步了解西治疗抑郁症的机制.
试点数据将产生该组合的抗抑郁作用及其对迷幻体验的影响.

结论:

将psilocybin与risperidone结合使用可能为TRD提供一种新的治疗方法.
这种方法可能会通过减轻迷幻效应来提高psilocybin治疗的可接受性和可访问性.
进一步的研究可能会导致不需要持续监测的抑郁症西治疗方法.

关键词:

治疗耐药性抑郁症的治疗方法大型抑郁症主要是抑郁症.这种药物是psilocybin.迷幻药辅助心理治疗是一种心理治疗.随机对照试验是一种随机对照试验.

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