年轻患者的长期COVID:使用多检测器CTCT评估对肺体积的影响
Davide Bellini1, Paola Capodiferro2, Simone Vicini2
1Department of Medical-Surgical Sciences and Biotechnologies, Sapienza University of Rome-Academic Diagnostic Imaging Division, I.C.O.T. Hospital, Via Franco Faggiana, 1668, 04100 Latina, Italy.
概括
定量分析显示,在长期COVID患者中,轻度呼吸道症状的肺部体积减少了10%. 这一发现突显了COVID-19的潜在长期影响,即使是正常的胸部CT扫描.
科学领域:
- 肺部医学 肺部医学
- 放射学 放射学是一门学科.
- 传染性疾病 传染性疾病
背景情况:
- 长期COVID的特点是,在一些人中持续出现轻微的呼吸道症状.
- 这些患者的胸部CT扫描通常看起来正常,缺乏明显的炎症发现.
- 对肺体积的定量分析可能会揭示在标准放射学检查中没有明显的微妙变化.
研究的目的:
- 通过对胸部CT图像进行定量分析,评估长期COVID患者的肺体积减少.
- 为了比较后COVID个体中轻度呼吸道症状的肺体积与非COVID对照组.
- 为了调查与长期COVID相关的潜在的亚放射性肺部变化.
主要方法:
- 对年轻成年患者 (18-40岁) 的胸部CT扫描进行了回顾性分析.
- 使用AwServer胸部VCAR软件进行定量体积分析.
- 排除具有炎症发现,先前的肺部手术,癌症或图像工件的患者.
- 后COVID组 (SARS-CoV-2阳性) 与大流行前非COVID对照组之间的比较.
主要成果:
- 分析了154名患者的队列 (77名COVID后,77名非COVID).
- 两组之间在年龄,性别,肥胖或吸烟习惯方面没有显著差异.
- 后COVID患者显示总肺体积 (5.25 L对比5.72 L,p=0.01),右肺体积 (2.76 L对比3 L,p=0.01),左肺体积 (2.48 L对比2.72 L,p=0.01) 的统计学显著减少.
结论:
- 定量CT分析表明,与对照人群相比,长期COVID患者的肺体积平均减少10%.
- 这一定量发现表明长期COVID肺部体积的亚辐射变化,即使有负的炎症CT发现.
- 这些结果强调了定量成像在理解长期COVID潜在的长期肺部影响的实用性,超出了传统的放射性评估.
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