收缩半球的形态变化与中风后的功能结果有关
Juan-Juan Lu1, Xiang-Xin Xing2, Jiao Qu3
1School of Rehabilitation Science, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
The European journal of neuroscience
|July 25, 2023
概括
卒中幸存者在未受影响的半球中表现出显著的灰质损失和皮质变化,影响日常生活和感觉运动功能. 这些结构性改变与功能性结果的减少相关,突出显示了中风的广泛影响.
科学领域:
- 神经科学是一个神经科学.
- 神经学 神经学
- 放射学 放射学是一门学科.
背景情况:
- 卒中是导致长期残疾的主要原因,通常导致感官运动和认知障碍.
- 了解中风后收缩半球中的结构性大脑变化对于预测功能恢复至关重要.
- 形态变化可能是中风幸存者观察到的功能缺陷的基础.
研究的目的:
- 为了研究中风后患者的逆伤半球的形态变化.
- 探索这些结构变化与功能结果之间的相关性.
- 确定受影响的特定大脑区域及其与临床评估的关系.
主要方法:
- 结构性MRI用于分析27名中风后患者和20名健康对照者的灰质体积 (GMV),皮层厚度 (CT),化指数 (GI),深度 (SD) 和碎形维度 (FD).
- 使用基于voxel和基于表面的形态测量技术来检测显著的结构差异.
- 部分相关性分析检查了结构变化和功能评分 (MBI,BBS,FMA-UE,MMSE,MoCA) 之间的关系.
主要成果:
- 在与运动相关的皮质,头/皮质,边缘系统和小脑中观察到显著的GMV减少.
- 下部CT在前中部和语言回旋中发现,下部GI在上部状回旋和胰岛中发现.
- 与MBI和BBS分数相关的对抗性语言转录GMV;与FMA-UE分数相关的海马体GMV.
结论:
- 脑卒中后患者在逆伤半球表现出广泛的灰质损失和皮质形态变化.
- 这些结构变化与感觉运动功能和日常生活活动有显著的相关性.
- 这些发现强调了中风对整个大脑网络及其功能后果的影响.
更多相关视频
10:15Utilizing Repetitive Transcranial Magnetic Stimulation to Improve Language Function in Stroke Patients with Chronic Non-fluent Aphasia
Published on: July 2, 2013
17.9K
07:03Evaluation of Hemisphere Lateralization with Bilateral Local Field Potential Recording in Secondary Motor Cortex of Mice
Published on: July 31, 2019
6.8K
相关概念视频
01:28Lateralization
364
Brain lateralization refers to the division of mental processes and functions between the two hemispheres of the brain, a phenomenon that optimizes neural efficiency and underpins complex abilities in humans. This specialization allows each hemisphere to perform tasks where it has a comparative advantage, facilitating more refined cognitive capabilities across different domains.
364
01:05Cerebral Hemispheres
390
The human brain, a complex organ, is functionally divided into two cerebral hemispheres—left and right. These hemispheres are interconnected by a structure of paramount importance, the corpus callosum. This substantial bundle of neural fibers is not just a bridge between the hemispheres but a crucial element for the brain's comprehensive functioning. It enables efficient communication between the two hemispheres, allowing each side of the brain to control and receive sensory and motor...
390
01:10Higher Mental Functions of the Brain: Language
919
Language is a system of communication that allows the expression of thoughts, ideas, and feelings. The brain processes language in both hemispheres.
Language formation and comprehension take place in the dominant hemisphere. The dominant hemisphere is responsible for understanding the meaning of spoken, written, or sign language, as well as the ability to communicate. For most people, the left hemisphere is the dominant one. The right hemisphere, then, gives tone and emotional context to the...
Language formation and comprehension take place in the dominant hemisphere. The dominant hemisphere is responsible for understanding the meaning of spoken, written, or sign language, as well as the ability to communicate. For most people, the left hemisphere is the dominant one. The right hemisphere, then, gives tone and emotional context to the...
919
01:11Cerebrum: Anatomical Overview II
1.8K
Each cerebral hemisphere can be divided into three main regions. The outermost region, the cerebral cortex, is a thin layer (2 to 4 millimeters thick) made up of gray matter, consisting of neuron cell bodies, dendrites, glial cells, and blood vessels. The middle region, or white matter, is primarily composed of myelinated nerve fibers organized into three types of large tracts: association fibers, commissures, and projection fibers. Association fibers connect different areas within the same...
1.8K