食道癌的外科治疗趋势 食道癌的外科治疗趋势
Binay Thakur1, Mukti Devkota1, Asha Thapa2
1Department of Surgical Oncology. BP Koirala Memorial Cancer Hospital, Bharatpur, Nepal.
在尼泊尔,食道癌手术结果在15年内显著改善. 新辅助治疗和微创手术 (MIS) 的进展降低了食道癌患者的死亡率,增加了食道癌患者的长期存活率.
科学领域:
- 在瘤学瘤学.
- 手术瘤学手术瘤学
- 胃肠道手术 胃肠道手术
背景情况:
- 消化管癌的管理已经转向多式模式的方法,由于历史上糟糕的结果.
- 多模式治疗现在是食道癌的标准实践.
- 这项研究研究了尼泊尔的一个中心15年来食道癌症手术的趋势.
研究的目的:
- 为了评估食道癌症管理的变化.
- 为了评估15年内食道切除术的结果.
- 确定有助于提高食道癌患者的生存率的因素.
主要方法:
- 分析了547名患有食道或胃食道结癌的患者,这些患者在2001年至2018年期间接受了食道切除术.
- 为了分析趋势,患者被分为三个连续的5年期.
- 与新辅助治疗率,采用微创手术 (MIS),30天死亡率和整体存活率的比较.
主要成果:
- 新辅助治疗的显著增加,从9-13%增加到52% (p<.001).
- 微创手术 (MIS) 的急剧增加,从0%到80% (p<.001).
- 30天死亡率从8%降至1% (p=.01) 和5年整体存活率从17%增加至27% (p=.003).
结论:
- 在过去的15年里,食道癌患者的长期结果有所改善.
- 降低死亡率与MIS和新辅助疗法的整合有关.
- 该研究强调了在资源有限的环境中成功实施现代多式联络治疗策略.
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