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新生儿败血症的临床,细菌学概况和结果
Shraddha Siwakoti1, Rinku Sah2, Rupa Rajbhandari Singh3
1Department of Microbiology, B. P. Koirala Institute of Health Sciences, Dharan, Nepal. shraddha.
Journal of Nepal Health Research Council
|July 25, 2023
概括
尼泊尔的新生儿败血症经常是由多抗药生物体引起的,导致死亡率更高,住院时间更长. 紧急的预防策略对于打击新生儿抗菌素耐药性至关重要.
科学领域:
- 新生儿医学 新生儿医学
- 传染性疾病 传染性疾病
- 微生物学 微生物学
背景情况:
- 败血症对尼泊尔新生儿构成重大威胁,导致大量的发病率和死亡率.
- 了解新生儿败血症的临床和细菌学方面对于有效管理至关重要.
研究的目的:
- 调查培养阳性新生儿败血症的临床细菌学概况.
- 分析引起病原体的抗生素敏感性模式.
- 确定与新生儿败血症相关的临床结果,包括死亡率和住院时间.
主要方法:
- 在尼泊尔的一家三级护理中心进行了一年多的前性研究.
- 血液培养是在临床诊断出败血症的新生儿身上进行的.
- 标准微生物学方法用于病原体识别和抗菌素敏感性测试.
主要成果:
- 培养阳性新生儿败血症发生在10.3%的入院患者中,金黄色葡萄球菌是常见的病原体.
- 多种耐药生物 (MDROs) 占病例的41%,包括广泛耐药的グラム阴性细菌和耐甲素的金黄色葡萄球菌.
- 与非MDRO病例 (中位数3天) 相比,MDRO相关的败血症导致更高的住院死亡率 (92%) 和显著更长的住院时间 (中位数11天).
结论:
- 新生儿败血症中MDRO的高发病率需要立即实施有效的预防策略.
- 抗菌素耐药性是新生儿护理的一个关键挑战,与不良的临床结果相关.
- 打击抗菌素耐药性对于降低新生儿发病率和死亡率至关重要.
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