使用多基因风险评分来优先考虑最需要心血管疾病风险评估的个人
Ryan Chung1,2, Zhe Xu1,2, Matthew Arnold1,2
1British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care University of Cambridge United Kingdom.
Journal of the American Heart Association
|July 25, 2023
概括
多基因风险评分可以改善心血管疾病 (CVD) 风险评估. 将遗传数据与初级保健记录集成,可以有效地识别需要他类药物治疗的个体,优化资源配置并预防更多事件.
科学领域:
- 基因组学就是基因组学.
- 心血管医学 心血管医学
- 公共卫生 公共卫生
背景情况:
- 心血管疾病 (CVD) 构成了重大的公共卫生挑战.
- 系统地识别个人进行心血管疾病风险评估对于及时干预至关重要.
- 目前的风险评估方法可能无法充分利用遗传信息.
研究的目的:
- 为使用多基因风险评分 (PRS) 在识别个人心血管疾病 (CVD) 风险评估中提供定量证据.
- 为了比较PRS与初级保健记录相结合的效率,与单独的初级保健记录进行心血管疾病风险分层.
主要方法:
- 利用了来自108,685名参与者 (40-69岁) 的英国生物库数据,包括生物标志物,初级保健记录和遗传数据.
- 开发了使用年龄,冠状动脉疾病和中风的PRS以及常规心血管疾病风险因素的优先级工具.
- 采用性别特定的考克斯模型进行风险评估和人口健康建模.
主要成果:
- 优先考虑仅使用初级保健记录的个人需要对149名男性和280名女性进行查,以预防一个心血管疾病事件.
- 将PRS纳入优先排序,将需要查的人数减少到116名男性和180名女性,以预防相同的事件.
- 这表明高风险个体的识别更有效.
结论:
- 将多基因风险得分与初级保健记录相结合,提供了一种更有效的方法来优先考虑个人进行心血管疾病风险评估.
- 这种综合性方法可以通过减少不必要的评估来改善初级保健的资源配置.
- 加强高风险个体的识别,确保及时干预和改善心血管疾病事件的预防.
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