概述最近的一些发现,揭示了脂肪和癌症之间的联系
Parth Pandit1, Chaitanya Shirke2, Nirav Bhatia3
1Department of Pharmacology, University of Strathclyde, Glasgow, UK.
Endocrine, metabolic & immune disorders drug targets
|July 25, 2023
概括
肥胖症通过破坏荷尔蒙和细胞生长,显著增加癌症风险. 这篇评论探讨了肥胖如何推动癌症的发展,为新的治疗策略提供了见解.
科学领域:
- 在瘤学瘤学.
- 内分泌学 在内分泌学.
- 代谢综合征是代谢综合征的一种.
背景情况:
- 流行病学研究证实,肥胖与癌症发病率和死亡率增加之间存在强烈联系.
- 肥胖会破坏荷尔蒙平衡,尤其是勒丁和胰岛素等脂素,这些脂素与癌症的发病和转移有关.
- 具体的机制包括乳腺癌中勒素诱导的HER2上调和高胰岛素血与结直肠癌的关联.
结论:
- 肥胖通过复杂的荷尔蒙和代谢途径促进癌症的发展.
- 了解这些机制对于开发针对肥胖相关癌症的新型治疗策略至关重要.
- 本综述提供了一个全面的概述,以帮助开发创新的干预措施.
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