过重儿童肝脏脂肪,骨髓脂肪组织和骨矿物质密度
Idoia Labayen1,2,3, Cristina Cadenas-Sánchez1,2,3,4, Fernando Idoate5
1Institute for Sustainability & Food Chain Innovation (ISFOOD), Department of Health Sciences, Public University of Navarre, 31006 Pamplona, Navarre, Spain.
The Journal of clinical endocrinology and metabolism
|July 25, 2023
概括
肝硬化,而不是一般的肥胖,与儿童的骨髓脂肪增加有关,这降低了骨矿物质密度. 这表明肝硬化可能表明骨质疏松症风险和骨健康干预的目标.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 骨的新陈代谢 骨的新陈代谢
- 放射学 放射学是一门学科.
背景情况:
- 肝脂肪症 (脂肪肝) 与骨矿物质密度 (BMD) 的降低有关.
- 骨髓脂肪分量 (BMFF) 可能会在儿童肥胖症中调解这种关联.
- 了解这种关系对于儿科骨健康至关重要.
研究的目的:
- 研究前青少年儿童的腰椎 (LS) BMFF和LS-BMD之间的关联.
- 探索LS-BMFF是否在这个人群中调解肝脂肪和LS-BMD之间的关系.
主要方法:
- 磁共振成像 (MRI) 评估了肝脏脂肪和LS-BMFF.
- 双能X射线吸收计 (DXA) 测量了LS-BMD.
- 106名超重/肥胖的青春期前儿童参与了这项研究.
主要成果:
- LS-BMFF与LS-BMD相反相关 (r=-0.313,P=.001) 并与肝脏脂肪直接相关 (r=0.276,P=.005).
- 患有肝硬化症的儿童的LS-BMFF显著更高 (P=.003).
- 通过LS-BMFF,肝脏脂肪与下部LS-BMD之间的关联占50%.
结论:
- 肝硬化,而不是整体脂肪,与儿童骨髓脂肪增加有关.
- 增加骨髓脂肪与较低的骨矿物质密度有关.
- 肝硬化可能作为骨质疏松风险的生物标志物和骨健康干预的目标.
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