婴儿人类帕雷科病毒脑炎:一个回顾性单中心研究 (2017-2022)
Muayad Alali1, Kiet Tat2, Shannon Hamilton3
1Department of Pediatrics, Ryan White Center for Pediatric Infectious Diseases and Global Health, Indiana University School of Medicine, 705 Riley Hospital Drive, Indianapolis, IN, 46202, USA. muayad.alali20@gmail.com.
European journal of pediatrics
|July 25, 2023
概括
帕雷科病毒 (PeV) 可以导致严重的脑炎和败血症的症状在婴儿中,即使正常的脑脊液. 这项研究强调了在婴儿诊断中考虑PeV的重要性,特别是在发病率增加的时期.
科学领域:
- 儿童传染病 儿童传染病
- 病毒性脑炎是一种病毒性脑炎.
- 新生儿神经学 新生儿神经学
背景情况:
- 帕雷科病毒 (PeV) 是已知的导致90天以下婴儿脑炎和败血症的原因.
- 正常的脑脊液 (CSF) 参数并不排除PeV脑炎.
- 多重聚合酶连锁反应面板 (MEP) 对于诊断PeV至关重要,有可能避免长期使用抗生素和住院治疗.
研究的目的:
- 描述90天以下婴儿PeV脑炎的临床特征和结果.
- 为了确定PeV脑炎的发病率.
- 为了确定与PeV脑炎相关的模式和风险因素.
主要方法:
- 进行了一项回顾性队列研究.
- 包括年龄小于90天的婴儿,这些婴儿被评估为脑膜炎.
- 使用MEP识别PeV脑炎病例,并每年计算病率.
主要成果:
- 在2115名婴儿中发现了32例PeV脑炎 (1.5%).
- 所有病例的脑液分析都显示正常 (没有多细胞瘤,蛋白质/葡萄糖正常).
- 常见的表现包括发烧,皮疹,,败血症状综合征和发作;25%的患者需要进入PICU.
结论:
- 乳腺炎脑炎和类似败血症的综合征是年幼婴儿的重大问题,即使有正常的CSF.
- 典型的MRI发现可以帮助诊断.
- PeV呈现两年一度的季节性,在2018年和2022年观察到的最高率.
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