适合目的:为一项随机对照试验的研究方案,以个性化监测结肠镜检查对患结肠直肠癌风险较高的个体进行监测结肠镜检查
Jean M Winter1, Kathryn J Cornthwaite2, Graeme P Young2
1Cancer Research, College of Medicine and Public Health, Flinders University, Bedford Park, SA, Australia. jean.winter@flinders.edu.au.
International journal of colorectal disease
|July 25, 2023
概括
使用便免疫化学测试 (FIT) 进行个性化结肠直肠癌 (CRC) 查可以安全地延长高风险个体的结肠镜间隔. 这种方法减少了不必要的程序,节省了成本,并改善了患者的体验.
科学领域:
- 胃肠病学和肝病学
- 在瘤学瘤学.
- 预防医学 预防医学
背景情况:
- 医疗保健系统面临着对结直肠癌 (CRC) 监测的日益增长的需求.
- 结肠镜资源有限,需要有效的监测策略.
- 使用便免疫化学测试 (FIT) 个性化监测频率可能会降低医疗保健能力的负担.
研究的目的:
- 为了确定使用FIT延长监视结肠镜间隔的安全性,成本效益和患者接受度.
- 评估针对高风险个人进行CRC监测的个性化方法.
- 减少不必要的结肠镜检查和相关的医疗保健费用.
主要方法:
- 一个多中心,前性,随机对照试验,涉及1344名CRC风险较高的参与者.
- 参与者在前3年从FIT获得低便血红蛋白 (F-Hb) 结果被随机选择.
- 与预定间隔相比,干预组的监测结肠镜间隔延长了1年或2年. 主要终点:晚期瘤的发生率. 二级终点:成本效益和患者接受度.
主要成果:
- 这项研究旨在根据FIT结果确定延长结肠镜间隔的安全性和有效性.
- 它将提供关于这个个性化监控战略的成本效益的数据.
- 通过调查和离散选择实验来评估患者对延长间隔的接受度和经验.
结论:
- 较低的FIT结果可以安全地指导在高CRC风险的个体中延长结肠镜监测间隔.
- 这种个性化方法预计将减少不必要的结肠镜检查,从而节省医疗保健费用.
- 该研究预计,通过更为量身定制的监测策略,患者体验将得到改善.
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