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对二元乙醇-三乙混合物的深入研究,与其优良的溶解能力相关

Evamaria Hofmann¹, Anna Saridis¹, Didier Touraud¹

¹Institute of Physical and Theoretical Chemistry, University of Regensburg, 93053-Regensburg, Germany. evamaria.hofmann@ur.de.

Physical chemistry chemical physics : PCCP

|July 25, 2023

概括

溶解库尔库和四库尔库在乙醇-三乙烯混合物中得到增强. 乙醇分子与三氨酸相互作用,减少聚合并提高溶解度,尽管确切的机制仍然是推测性的.

科学领域:

物理化学物理化学
材料科学材料科学材料科学
制药科学制药科学

背景情况:

黄素和四黄素在许多常见溶剂中具有较差的溶解性.
开发有效的溶剂系统对于其配方和应用至关重要.
二元溶剂混合物通过协同效应提供了增强溶解性的潜力.

研究的目的:

为了研究黄素和四黄素在乙醇-三乙烯混合物中的协同溶解.
阐明分子相互作用和对增强溶解度负责的结构变化.
探索溶剂成分对溶解物聚合行为的作用.

主要方法:

预测相互作用的COSMO-RS理论计算.
动态光散射 (DLS) 和小和广角X射线散射 (SAXS/WAXS) 用于结构分析.
介电放松光谱 (DRS) 探测分子动力学和相互作用.

主要成果:

理论计算表明,增强的溶解性不仅仅是由于最佳的表面电荷相互作用.
散射实验排除了中介层结构作为溶解性增强的主要原因.
介电放松光谱显示,在特定度范围内 (0.3 ≤ x(triacetin) ≤ 0.6),乙醇分子的释放和与酸氨酸的相互作用导致了中光学聚合的减少.

结论:

该研究确定了乙醇-三乙烯混合物的特定度范围,该范围显著提高了 (四) 库尔库明的溶解性.
增强的溶解性与乙醇的聚合物网络的破坏以及与三酸的分子级相互作用有关.
尽管进行了详细的调查,但溶剂的溶化功率的确切来源仍然是推测性的,需要进一步研究.

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