6:2 化聚甲基乙醇硫酸盐对新生儿的甲状腺平衡具有比 perfluorooctanesulfonate 更强烈的破坏性影响:基于来自人口研究的贝叶斯基准剂量值的证据
Xin Liu1,2, Lei Zhang2, Jiaying Liu3
1College of Food Science and Engineering, Hubei Key Laboratory for Processing and Transformation of Agricultural Products, Wuhan Polytechnic University, Wuhan 430023, China.
新兴的 perfluoroalkyl 物质 (PFAS),如 6:2 化聚甲基乙烯硫酸盐 (Cl-PFESA),在新生儿中显示出比传统的 PFAS 更大的甲状腺干扰. 这项研究发现 6:2 Cl-PFESA比 perfluorooctanesulfonate (PFOS) 更强效,突出了PFAS替代品的风险.
科学领域:
- 环境毒理学环境毒理学
- 内分泌学 在内分泌学.
- 人类健康风险评估
背景情况:
- 越来越多的证据表明,新出现的和多基物质 (PFAS) 可能会带来重大毒理风险.
- 化聚甲基乙烯硫酸盐 (Cl-PFESA) 是一种新兴的PFAS,对人类健康风险评估数据有限.
- 传统的PFAS如 perfluorooctanesulfonate (PFOS) 和 perfluorooctanoic acid (PFOA) 是众所周知的内分泌干扰剂.
研究的目的:
- 调查新兴和传统的PFAS暴露对新生儿甲状腺平衡的影响.
- 用基准剂量方法比较 6:2 Cl-PFESA 和 PFOS 的甲状腺破坏潜力.
- 评估与混合和单个PFAS暴露相关的人体健康风险.
主要方法:
- 利用部分最小平方 (PLS) 模型来估计混合PFAS暴露对健康的影响.
- 采用线性回归来分析个人PFAS暴露的影响.
- 进行贝叶斯基准剂量 (BMD) 分析以确定BMD值,以比较6:2Cl-PFESA和PFOS毒性.
主要成果:
- 发现 6:2 Cl-PFESA,PFOS和PFOA的中位数度在新生儿中是相似的.
- 在PLS模型中, 6:2 Cl-PFESA被确定为对预测 (VIP评分) 最重要的物质,其次是PFOS和PFOA.
- 6:2 Cl-PFESA与自由三甲氨酸 (FT3) 和三甲氨酸 (T3) 有显著的积极关联;PFOS与FT3.3有边际关联.
- 骨质量分析表明,与PFOS (1.66 ng/mL) 相比, 6:2 Cl-PFESA (1.01 ng/mL) 的BMD10较低,FT3.3增加了10%.
结论:
- 6:2 Cl-PFESA对新生儿甲状腺稳态的影响比PFOS更为明显.
- 新兴的PFAS,如6:2 Cl-PFESA,可能比传统的PFAS带来更大的甲状腺功能障碍风险.
- 调查结果强调,需要对替代PFAS化学品进行严格的人类健康风险评估.
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