皮罗尼病的非手术治疗方法
Joel E Rosenberg1, Onuralp Ergun2,3, Eu Chang Hwang4
1Department of Urology, University of California San Diego, San Diego, California, USA.
对皮罗尼病的非手术治疗方法的有效性有限,注射的原酶提供了一些益处,但增加了不良事件. 为了更好的治疗选择,需要更多的研究.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 安德罗学与人类学
- 基于证据的医学基于证据的医学.
背景情况:
- 皮罗尼氏病涉及阴茎斑块导致曲,疼痛和勃起功能障碍,影响性活动.
- 像注射和机械方法这样的非手术干预措施存在,但它们的有效性是不确定的.
研究的目的:
- 为了评估与安慰剂或没有治疗相比,非手术治疗对皮罗尼氏病男性的影响.
- 为了确定对阴茎曲线,性功能,生活质量和不良事件的影响.
主要方法:
- 在多个数据库和灰色文献来源中进行全面的文献搜索,直到2022年9月.
- 包括随机对照试验 (RCT),比较非手术治疗与安慰剂或没有治疗.
- 使用随机效应模型进行数据提取和分析,以GRADE评级的证据确定性.
主要成果:
- 有限的证据支持大多数非手术治疗方法;试验通常具有糟糕的方法或缺乏以患者为中心的结果.
- 注射的原酶对生活质量和曲率有一定的短期有效性,但不良事件增加.
- 对注射维拉帕米尔,体外冲击波治疗 (ESWT) 和阴茎引疗法的证据非常不确定.
结论:
- 大多数皮罗尼病的非手术治疗方法缺乏有效性的强有力的证据.
- 注射式原酶提供了一些潜力,但对许多患者来说存在风险和不确定的临床相关性.
- 对改善皮罗尼病的非手术治疗方案进行高质量的研究有很大的需求.
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