整合多经济学和先验知识:对Graphnet惩罚影响影响的研究
Hamza Chegraoui1, Vincent Guillemot2, Amine Rebei1
1Université Paris-Saclay, CEA, Neurospin, 91191 Gif-sur-Yvette, France.
Bioinformatics (Oxford, England)
|July 25, 2023
概括
多块模型中的图形惩罚增强了基因选择,并改善了瘤学中的生存预测性能. 不同的图表产生一致的结果,图形密度是关键因素.
科学领域:
- 在瘤学瘤学.
- 生物信息学是一种生物信息学.
- 统计建模 统计建模
背景情况:
- 在瘤学中,统计模型对于识别影响疾病发展和结果的因素至关重要.
- 多块框架整合了多原子数据,变量选择通常以模型参数约束为指导.
- априори图的约束增强了特征选择和模型可解释性,但它们的相互作用和影响需要进一步研究.
研究的目的:
- 调查图形罚款对多块模型的影响,特别是Sparse Group CCA (SGCCA).
- 分析不同图形结构如何影响癌症数据中的特征选择和模型性能.
- 评估图形惩罚对多块模型的可解释性和预测能力的影响.
主要方法:
- 使用SGCCA框架进行多块分析.
- 应用图形惩罚来限制模型参数和指导变量选择.
- 分析了TCGA-LGG数据集,以评估图形处罚的影响.
主要成果:
- 图形惩罚增加了所选基因的数量,识别了已知的生物标志物.
- 不同的图表产生了一致而又独特的结果,图形密度是主要影响因素.
- 图形处罚提高了生存预测性能,提高了模型的解释性.
结论:
- 图形惩罚在增强瘤多块模型中的特征选择和可解释性方面是有效的.
- 图形的选择,特别是它的密度,显著影响模型结果.
- 拟议的方法提高了使用多组数据进行生存分析的预测性能.
相关概念视频
Multi-input and Multi-variable systems
129
Cruise control systems in cars are designed as multi-input systems to maintain a driver's desired speed while compensating for external disturbances such as changes in terrain. The block diagram for a cruise control system typically includes two main inputs: the desired speed set by the driver and any external disturbances, such as the incline of the road. By adjusting the engine throttle, the system maintains the vehicle's speed as close to the desired value as possible.
In the absence...
In the absence...
129
Protein Networks
2.4K
2.4K
Genomics
36.5K
Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
36.5K
End Point Prediction: Gran Plot
386
A Gran plot is used to predict the equivalence volume or endpoint of a potentiometric or acid-base titration without reaching the endpoint. Typically, titration data is collected as a function of the titrant's volume up to a point less than the equivalence volume and then transformed into a linear format. The straight line is extended to the x-axis, indicating the necessary titrant volume to achieve the equivalence point.
For potentiometric titration, the Gran plot is created by plotting...
For potentiometric titration, the Gran plot is created by plotting...
386
Neural Circuits
1.3K
Neural circuits and neuronal pools are two of the main structures found in the nervous system. Neural circuits are networks of neurons that work together to carry out a specific task or process. They consist of interconnected neurons and glial cells, which provide structural and metabolic support.
Neuronal pools are collections of nerve cells with similar functions and interact through chemical and electrical signals. These pools include both interneurons (the central neural circuit nodes that...
Neuronal pools are collections of nerve cells with similar functions and interact through chemical and electrical signals. These pools include both interneurons (the central neural circuit nodes that...
1.3K
Improving Translational Accuracy
11.6K
Base complementarity between the three base pairs of mRNA codon and the tRNA anticodon is not a failsafe mechanism. Inaccuracies can range from a single mismatch to no correct base pairing at all. The free energy difference between the correct and nearly correct base pairs can be as small as 3 kcal/ mol. With complementarity being the only proofreading step, the estimated error frequency would be one wrong amino acid in every 100 amino acids incorporated. However, error frequencies observed in...
11.6K


