抑郁症状长度介导高血糖对2型糖尿病记忆力下降的影响
A Zarina Kraal1, Vicki L Ellingrod2, Laura B Zahodne3
1Department of Neurology, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, NY.
Diabetes care
|July 25, 2023
概括
在患有2型糖尿病的老年人中,高血糖 (高血糖) 可以随着时间的推移恶化记忆,抑郁症作为关键环节. 控制血糖和抑郁症可能会保护认知功能.
科学领域:
- 老年学是指老年学的学科.
- 神经科学是一个神经科学.
- 内分泌学 在内分泌学.
背景情况:
- 慢性高血糖是2型糖尿病 (T2D) 的标志,通常与老年人的认知能力下降有关.
- 抑郁症状在T2D中很普遍,可能会影响认知轨迹.
- 了解高血糖,抑郁和认知之间的相互作用对于有效的管理策略至关重要.
研究的目的:
- 研究慢性高血糖和纵向认知功能之间的关系中抑郁症状变化的调解作用.
- 检查高血糖症对情节性记忆的6年影响,抑郁症状作为T2D老年人潜在的调解者.
主要方法:
- 使用结构方程建模对2,155名患有T2D的美国成年人 (≥51岁) 的观察数据进行了纵向调解分析.
- 基线HbA1c的评估,两个时间点 (4年间隔) 的抑郁症状,以及6年内的情节性记忆.
- 调整社会人口统计,并发症,药物坚持,以及先前的认知和抑郁症状得分.
主要成果:
- 在4年内,较高的基线HbA1c水平与抑郁症状的增加有关.
- 2年后,抑郁症状的增加预测了较差的情节性记忆.
- 抑郁症状占HbA1c在6年内对记忆的纵向影响的19%.
结论:
- 抑郁症状的发生率上升显著调解了T2D老年人高血糖症和纵向情节性记忆衰退之间的关联.
- 针对HbA1c相关的抑郁症状的干预措施可以减轻慢性高血糖症对认知的神经毒性影响.
- 预防高血糖引起的抑郁症可能是保持这一群体认知功能的一种策略.
相关概念视频
Psychoneuroimmunology: Diabetes and Cancer
48
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
48
Diabetes Mellitus: Type 2 and Gestational
2.5K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
2.5K
Diabetes: Symptoms, Diagnosis, and Complications
595
For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
595
Pathophysiology of Diabetes
996
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
996
Diabetes Mellitus: Overview and Type I Subtype
2.8K
Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
2.8K
Carbohydrate Metabolism
11.3K
Carbohydrates are polymers composed of molecules containing atoms of carbon, hydrogen and oxygen. One gram of carbohydrate can provide four kilo-calories of energy, which makes it the most efficient instant energy source.
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
11.3K


