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[癌症患者中白金诱导的外围神经病变的机制]
S V Chubykina1, M Yu Tatarinova1, G G Avakyan1
1Pirogov Russian National Research Medical University, Moscow, Russia.
化疗诱导的多神经病变 (CIPNP) 是基药物的重要副作用,影响癌症患者. 本综述探讨了CIPNP的情况.
科学领域:
- 在瘤学瘤学.
- 神经学 神经学
- 药理学 药理学是指药理学的学科.
背景情况:
- 化疗诱导的多神经病变 (CIPNP) 是基化疗剂的普遍和衰弱的副作用.
- 通过影响运动,感觉和自主功能,CIPNP显著损害患者的生活质量,在治疗停止后经常持续很长时间.
- 癌症发病的不可预测性,缺乏早期预测性标记物,以及缺乏有效的预防或治疗药物,在癌症护理中构成了重大挑战.
研究的目的:
- 审查与基化疗药物相关的神经毒性.
- 探索CIPNP的发病率,风险因素和病原遗传机制.
- 描述化疗诱导的多神经病变的临床和神经生理特征.
主要方法:
- 对基化疗和神经毒性研究的文献综述.
- 对CIPNP的临床和临床前数据的分析.
- 综合有关CIPNP风险因素,机制和临床表现的信息.
主要成果:
- CIPNP会影响运动,感觉和自主功能,往往在治疗后持续存在.
- 预测CIPNP的发病,严重程度和时间是具有挑战性的.
- 目前的治疗方法缺乏有效的预防或缓解CIPNP的策略.
结论:
- 由于其不可预测的性质和持续的症状,CIPNP代表了癌症治疗中的重大临床挑战.
- 对预测标记物和新的治疗策略进行进一步的研究是有必要的,以减轻白金诱导的神经毒性.
- 本综述提供了一个全面的概述,以指导临床实践和未来的研究方向.
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