接触生物杀伤剂TiO2 通过使用化学稳定的酸盐启动剂进行表面启动的原子转移激进聚合,使表面表面变质
Eilika Zorn1, J Iven H Knaack1, Nils Burmeister1
1Department of Chemistry, University of Hamburg, Bundesstraße 45, 20146 Hamburg, Germany.
Langmuir : the ACS journal of surfaces and colloids
|July 25, 2023
概括
研究人员开发了双功能启动器,用于在上进行表面启动的原子转移基聚合 (SI-ATRP). 较长的启动器间隔器增强了聚合物接种,创造了稳定的多化表面,具有强大的抗菌活性,可以对抗S. aureus.
科学领域:
- 材料科学 材料科学 材料科学
- 聚合物化学 聚合物化学
- 表面化学 表面化学
背景情况:
- 表面启动的原子转移基聚合 (SI-ATRP) 能够从表面上进行功能性聚合物接种.
- 在金属表面上固定启动器对于SI-ATRP至关重要.
- 酸组促进了表面结合,而化胺部分则使SI-ATRP.
研究的目的:
- 为了研究二功能启动器中基间隔器长度对表面聚合物接种的影响.
- 为了创建具有抗微生物特性的稳定聚化表面.
- 建立一个高效的SI-ATRP协议,避免有毒试剂.
主要方法:
- 用酸和异胺基组合成双功能启动剂.
- 使用这些启动器对的表面进行修改.
- 表面启动的 (乙烯基) 三甲基化 (VBTAC) 的原子转移基聚合 (SI-ATRP).
- 分析聚合物厚度,电荷密度和抗菌活性.
主要成果:
- 聚合物接种厚度随着启动器间距长度的增加而增加.
- 实现了高的表面电荷密度 (∼10^16 N+/cm^2).
- 经过修改的表面表现出有效的接触活性,可以对抗金黄色葡萄球菌.
- 与VBTAC一起的SI-ATRP被证明是有效的,绕过了移植后的四级化.
结论:
- 具有酸组的双功能启动器对上的SI-ATRP有效.
- 基间距长度是控制聚合物接种的关键参数.
- 开发的方法产生了高电荷的抗微生物表面,没有有毒试剂.
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