基于多药丸的策略与心血管疾病的二次预防的常规护理:随机对照试验的元分析
André Rivera1, Bruno Campos2, Stephanie Ceolin3
1Department of Medicine, Nove de Julho University, São Bernardo do Campo, Brazil.
European journal of preventive cardiology
|July 25, 2023
概括
基于多种药丸的策略 (PBS) 改善了药物坚持,并减少了心血管疾病 (CVD) 患者的心血管死亡率. 与通常的护理相比,这种方法也可以适度降低血压和LDL胆固醇.
科学领域:
- 心脏病学 心脏病学
- 药理学 药理学是指药理学的学科.
- 公共卫生 公共卫生
背景情况:
- 心血管疾病的二次预防对于降低死亡率至关重要.
- 治疗坚持仍然是一个挑战,在管理慢性疾病,如心血管疾病.
- 基于多种药丸的策略 (PBS) 提供了一种简化的药物管理方法.
研究的目的:
- 系统地审查和元分析随机对照试验 (RCT).
- 确定基于多种药丸的策略 (PBS) 对治疗坚持和心血管结果的影响.
- 为了比较PBS与心血管疾病的二次预防的通常护理.
主要方法:
- 系统地搜索PubMed,Cochrane和Scopus数据库,直到2023年1月.
- 包括8个RCT,6541名参与者比较PBS与常规护理.
- 评估治疗坚持,缩血压 (SBP),LDL胆固醇 (LDL-C) 和死亡率的结果.
主要成果:
- PBS显著增加了治疗坚持 (RR 1.22;P < 0.001).
- PBS与显著降低心血管死亡率有关 (RR 0.61;P = 0.004).
- PBS导致SBP (MD-1.47 mmHg; P = 0.04) 和LDL-C (MD-3.83 mg/dL; P = 0.02) 的显著降低.
结论:
- 基于多种药丸的策略 (PBS) 改善了先前存在心血管疾病的患者的治疗坚持.
- PBS与心血管死亡率降低和SBP和LDL-C的适度降低有关.
- 在心血管疾病患者中,PBS可能是二次预防的首选策略.
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