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Fabricating a Kidney Cortex Extracellular Matrix-Derived Hydrogel
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新疗法:水凝可以治疗脏疾病吗?
Danielle E Soranno1,2, Christopher B Rodell3
1Department of Pediatrics, Pediatric Nephrology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Nephron
|July 25, 2023
概括
可以注射的水凝可以提高治疗性细胞存活率,用于治疗脏疾病. 这些先进的材料改善了细胞输送,并在临床前模型中显示出有前途,减少炎症和纤维化而不会损害功能.
科学领域:
- 生物材料科学 生物材料科学
- 再生医学是一种再生医学.
- 药物输送系统 药物输送系统
背景情况:
- 水凝是水膨胀的多功能聚合物网络,可适应各种治疗应用.
- 可注射的水凝配方方便在现场提供敏感的治疗药物,如细胞和细胞因子.
- 众多的聚合物化学可以创建具有定制性质的注射水凝.
研究的目的:
- 在病的临床前模型中审查可注射水凝的应用.
- 总结用于基于水凝的病研究的材料,治疗有效载荷和动物模型.
- 评估病治疗中水凝疗法的安全性和有效性.
主要方法:
- 对脏疾病的注射水凝现有文献的综述.
- 分析使用各种天然和合成聚合物基水凝的研究.
- 检查封装的治疗有效载荷,包括细胞和细胞因子.
- 对病的临床前动物模型 (老鼠,大鼠) 的评估.
主要成果:
- 与传统悬浮剂相比,可注射的水凝显著提高了输送细胞的存活率.
- 单独使用水凝治疗已经证明有效减少脏炎症和纤维化.
- 通过皮肤测量膜过率证实,在囊下输送水凝后,功能没有受损.
结论:
- 可以注射的水凝是提供治疗治疗病的安全有效平台.
- 基于水凝的疗法显示出降低炎症和纤维化等关键病理标志物的潜力.
- 对水凝材料和治疗有效载荷的进一步研究可以推进对脏疾病的再生医学方法.
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