通过心脏设备减少感染封面:从现实世界的数据中获得洞察力. 这就是REINFORCE项目
Matteo Ziacchi1, Mauro Biffi1, Saverio Iacopino2
1Institute of Cardiology, IRCCS Azienda Ospedaliero Universitaria di Bologna, Via Massarenti 9, 40125 Bologna, Italy.
概括
在现实患者中,TYRXTM可吸收抗生素释放包裹显著降低了心脏植入式电子设备 (CIED) 感染. 这种对CIED感染的保护作用在五年内被观察到.
科学领域:
- 心脏病学 心脏病学
- 传染性疾病 传染性疾病
- 生物材料是一种生物材料.
背景情况:
- 心脏植入式电子设备 (CIED) 感染对患者和医疗保健系统构成重大风险.
- 可吸收的TYRXTM抗生素排泄封面旨在减轻这些感染风险.
- 现实世界的数据对于验证此类干预措施的有效性至关重要.
研究的目的:
- 评估TYRXTM可吸收抗生素排泄包裹对感染相关临床事件的现实影响.
- 为了评估信封在当代,多样化的患者群体中进行CIED手术的有效性.
主要方法:
- 从接受CIED植入的患者收集前性数据.
- 接受抗生素排泄包裹的患者和对照组之间的感染率的比较.
- 统计分析感染相关事件的平均随访时间为1.4年,累计发病率为5年.
主要成果:
- 该研究包括1819名患者;872人使用信封,947人没有使用信封.
- 接收信封的患者在1.4年内感染相关事件的发生率显著降低 (0.8%对2.4%,P = 0.007).
- 感染相关事件的五年累计发病率在包裹组明显较低 (2.1%与8.1%相比).
结论:
- 使用TYRXTM可吸收抗生素排泄封面与CIED感染的风险降低有关.
- 这包括全身和口袋感染.
- 这些发现支持使用抗生素泄露包裹来改善CIED患者的治疗结果.
相关概念视频
Endocarditis III: Medical Management
8
Infective endocarditis management involves a multifaceted approach encompassing infection prevention, lifestyle modifications, pharmacological therapy, and surgical management.Infection Prevention:Hand Hygiene: Thorough handwashing is crucial to prevent the spread of infection. Hand hygiene should be performed regularly, especially before and after using the restroom.Oral Hygiene: Good oral hygiene is essential. It includes brushing teeth immediately after waking up and before bed, flossing...
8
Healthcare Associated Infections II: Preventive Measures
2.7K
Essential infection prevention measures are based on the knowledge of the infection chain, the modes of transmission in healthcare settings, and the use of the best practices in all healthcare settings. Compulsory public reporting of healthcare-associated infection rates is needed to allow individuals and the community to make informed choices regarding selecting a healthcare facility.
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
2.7K
Endocarditis I: Introduction
13
Introduction:Endocarditis is the infection of the endocardium, the inner lining of the heart and its valves. When the heart muscle is involved, the condition is termed myocarditis, while an infection of the outer lining is called pericarditis. Infective endocarditis (IE) primarily affects the endocardium, where pathogens adhere to the valves or lining, forming vegetation that can lead to severe complications. Infective endocarditis occurs when microorganisms, usually bacteria from other body...
13
Bacterial Signaling
32.8K
Bacterial signaling can occur within bacteria (intracellular) or between bacteria (intercellular). At times, a group of bacteria behaves like a community. To achieve this, they engage in quorum sensing, the perception of higher cell density that causes changes in gene expression. Quorum sensing involves both extracellular and intracellular signaling. The signaling cascade starts with a molecule called an autoinducer (AI). Individual bacteria produce AIs that move out of the bacterial cell...
32.8K


