在轻度至中度急性胰腺炎患者中补充纳米黄素:一个随机的,安慰剂控制的试验
Maedeh Chegini1, Amir Sadeghi2, Farid Zaeri3
1Department of Clinical Nutrition, National Nutrition and Food Technology Research Institute, School of Nutrition and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Phytotherapy research : PTR
|July 25, 2023
概括
纳米,一种抗炎药物,显著减少了轻度至中度急性胰腺炎 (AP) 患者的住院时间和止痛需求. 这种安全的辅助疗法也改善了食欲,这表明对AP恢复的潜在益处.
科学领域:
- 胃肠病学和肝病学
- 药理学和治疗学 药理学和治疗学
背景情况:
- 急性胰腺炎 (AP) 是一种严重的胃肠道疾病,严重程度各不相同.
- 目前的管理重点是支持性护理,需要有效的辅助疗法来改善患者的治疗结果.
研究的目的:
- 评估纳米黄素作为轻度至中度急性胰腺炎患者的抗炎药物的疗效和安全性.
- 评估纳米黄素对胃肠病房停留时间,止痛药需求和食欲的影响.
主要方法:
- 进行了一项双盲,并行臂随机对照试验,其中42名患者被诊断为轻度至中度AP.
- 参与者接受了纳米库尔库明 (40毫克每天两次) 或安慰剂两周.
- 主要终点是胃肠病房停留时间;次要终点包括止痛药的使用和食欲得分.
主要成果:
- 纳米黄素补充剂显著减少了住院时间 (RR=0.67,p=0.006).
- 随着时间的推移,接受纳米黄素的患者需要更少的止痛药 (OR=0.576,p=0.001) 并报告了整体食欲的改善 (β=0.104,p=0.049).
- 没有观察到任何不良反应或死亡率,在研究期间没有患者退出.
结论:
- 纳米黄素证明了安全性和潜力,作为轻度至中度急性胰腺炎的辅助疗法.
- 它可以有效地减少胃肠病房停留时间,减少止痛药的需求,提高食欲.
- 需要进一步的多中心试验和更大的队列来证实这些有希望的发现.
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