COVID-19,G蛋白结合受体和氨酸 - 血管新生素系统自身抗体:系统性审查和元分析
Abolfazl Akbari1, Alireza Hadizadeh2, Muhammad Islampanah1
1Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Autoimmunity reviews
|July 25, 2023
概括
针对G蛋白结合受体 (GPCRs) 和氨酸- ангиотензин系统 (RAS) 的自身抗体 (AAbs) 在COVID-19中越来越多地被报告. 这一系统性审查发现COVID-19患者的ACE2 AAbs显著更高,这表明疾病严重程度和长期症状的作用.
科学领域:
- 免疫学 免疫学 免疫学
- 心血管研究研究心血管研究
- 传染性疾病 传染性疾病
背景情况:
- 越来越多的证据将自身抗体 (AAbs) 与宿主蛋白,包括G蛋白结合受体 (GPCRs) 和氨酸-血管新生系统 (RAS) 与COVID-19联系起来.
- 这些AAbs可能会导致疾病的发病和持续的症状.
研究的目的:
- 在COVID-19患者中系统地审查和元分析对GPCR和RAS的AAbs的流行率.
- 调查这些AAbs和COVID-19严重程度之间的关联,包括长期COVID和后COVID症状.
主要方法:
- 在PubMed,Embase,Web of Science和Scopus数据库中进行全面的文献搜索,截至2023年3月21日.
- 对68项选定的研究进行系统审查和元分析,其中9项用于元分析.
- 关于 ангиотензинII (AngII) 或 ангиотензин转化酶 (ACE) AAbs 的流行率及其与COVID-19状态和严重程度的关联的数据.
主要成果:
- 分析包括68项研究的数据.
- 在COVID-19患者 (OR=7.766,p=0.002),特别是严重病例 (OR=11.49,p=0.046) 中,观察到ACE2 AAbs显著更高的血清阳性.
- 在COVID-19患者和对照人群 (OR=2.890,p=0.21) 之间没有发现 ангиотензинII (AngII) -AAbs血清阳性显著差异.
结论:
- GPCR和RAS AAbs,特别是ACE2 AAbs,似乎在COVID-19严重性中发挥着重要作用.
- 这些自身抗体可能有助于疾病的进展和长期和后COVID症状的发展.
- 需要进一步的研究来阐明这些AAbs的确切机制和临床影响.
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