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Updated: Jul 21, 2025

Development of a 68Gallium-Labeled D-Peptide PET Tracer for Imaging Programmed Death-Ligand 1 Expression
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强效和选择性d-激素的葡萄糖类-2受体的计算设计

Pedro A Valiente1, Satra Nim1, Jisun Kim1

  • 1Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario M5S 3E1, Canada.

Journal of medicinal chemistry
|July 25, 2023
PubMed
概括

研究人员开发了新的d-GLP-2主动剂,激活类似葡萄糖素的-2受体 (GLP-2R),以增强AKT酸化. 这些稳定的激动剂显示出治疗炎症性肠病和改善肠道吸收的潜力.

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Incretins include glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), which stimulate insulin secretion post-meals. In type 2 diabetes, GIP's efficacy is reduced, making GLP-1 a viable drug target. GIP originates from preproGIP.
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