对于健康怀孕的血液静止生物标志物的三季度特定参考间隔
Haijun Xiao1, Weijian Yu1, Lihua Li1
1Shenzhen Baoan Women's and Children's Hospital, Guangdong, P.R. China.
概括
这项研究建立了健康怀孕中关键血液静止生物标志物的三个月特定参考间隔. 这些参考范围,包括血-抗血复合物 (TAT) 和其他,有助于监测与怀孕相关的静血变化.
科学领域:
- 生殖生物学 生殖生物学
- 临床生物化学 临床生物化学
- 血液学 血液学 血液学
背景情况:
- 血液静止在怀孕期间经历了显著的生理变化.
- 确定血静生物标志物的准确参考间隔对于对母亲健康进行监测至关重要.
- 现有的数据可能无法完全捕捉整个妊娠期间血液静止的动态变化.
研究的目的:
- 为了确定健康怀孕中四个关键的血液静止生物标志物的参考间隔.
- 为了提供血栓-抗血栓复合物 (TAT),α2-等离子体抑制剂-等离子体复合物 (PIC),血栓模块素 (TM) 和组织等离子体激活剂-抑制剂复合物 (tPAI-C) 的三个月具体参考范围.
- 为了建立一个基线来识别怀孕期间潜在的静血异常.
主要方法:
- 在HISCL自动分析仪上进行定量化学发光酶免疫测试.
- 包括496名不同季度的健康孕妇和103名非孕妇.
- 生物标志物度的中位数和参考区间 (2.5至97.5百分位数) 的计算.
主要成果:
- 为TAT,PIC,TM和tPAI-C.建立了三季度特定的参考间隔.
- 在整个怀孕期间,TAT度呈现一致的增加.
- 对于非孕妇的参考间隔被发现不适用于孕妇.
结论:
- 该研究为健康怀孕中TAT,PIC,TM和tPAI-C提供了重要的妊娠参考间隔.
- 这些确定的间隔对于准确解释怀孕期间的血液静止生物标志物结果至关重要.
- 监测这些生物标志物可以帮助早期发现与怀孕有关的静血并发症.
相关概念视频
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
119
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
119
Anticoagulant Drugs: Low-Molecular-Weight Heparins
755
Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
755
Disorders of Hemostasis
992
Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
992
Introduction to Hemostasis
8.3K
Hemostasis is a complex physiological process that prevents excessive bleeding when a blood vessel is injured. It's crucial for maintaining the integrity of the circulatory system, as it ensures that our blood remains fluid while still within the vascular network and yet clots to prevent blood loss upon vessel injury.
The three phases of hemostasis involve many clotting factors present in plasma and several substances released by platelets and injured tissue cells. It is a fast, localized,...
The three phases of hemostasis involve many clotting factors present in plasma and several substances released by platelets and injured tissue cells. It is a fast, localized,...
8.3K
Blood Studies for Cardiovascular System I: Cardiac Biomarkers
201
Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
201
Venous Thrombosis III: Interprofessional Care
10
Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
10


