优化线粒体功能作为在出血性休克中复活的新目标:系统性审查
Laura Cottey1, J E Smith2,3, S Watts4
1Academic Department of Military Emergency Medicine, Royal Centre for Defence Medicine, Birmingham, UK laura.cottey@nhs.net.
BMJ military health
|July 25, 2023
概括
线粒体在创伤和出血性休克中起着关键作用. 优化线粒体功能为改善严重受伤患者的治疗结果提供了一个有希望的治疗目标,特别是在偏远环境中.
科学领域:
- 创伤和紧急医疗医学
- 细胞生物学 细胞生物学
- 线粒体医学 线粒体医学
背景情况:
- 创伤伤害是全球主要的死亡原因,严重受伤患者的生存率停滞不前.
- 需要创新的治疗方法,特别是在偏远或严格的环境中,疏散时间延长.
- 线粒体对细胞平衡至关重要,可能在创伤患者的治疗结果中起着关键作用.
研究的目的:
- 系统地审查关于线粒体在创伤和出血性休克中的作用的文献.
- 确定旨在优化创伤患者线粒体功能的治疗方法的当前证据.
主要方法:
- 按照PRISMA指南进行了一次系统的文献审查.
- 如果在创伤和出血性休克模型中评估了针对线粒体的治疗方法,并测量了线粒体功能,则将研究纳入.
主要成果:
- 在最初的918篇文章中,审查发现了37篇相关研究.
- 治疗针对受创伤和出血性休克影响的关键线粒体通路,包括ATP水平,细胞死亡,氧化应激和活性氧物种.
结论:
- 线粒体优化是一种可行的和有价值的治疗策略,可以改善严重受伤患者的治疗结果.
- 了解线粒体功能对于推进创伤护理至关重要,特别是在资源有限的环境中.
更多相关视频
相关概念视频
01:46Electron Transport Chain: Complex I and II
14.5K
The mitochondrial electron transport chain (ETC) is the main energy generation system in the eukaryotic cells. However, mitochondria also produce cytotoxic reactive oxygen species (ROS) due to the large electron flow during oxidative phosphorylation. While Complex I is one of the primary sources of superoxide radicals, ROS production by Complex II is uncommon and may only be observed in cancer cells with mutated complexes.
ROS generation is regulated and maintained at moderate levels necessary...
ROS generation is regulated and maintained at moderate levels necessary...
14.5K
01:45Mitochondrial Membranes
11.6K
A single mitochondrion is a bean-shaped organelle enclosed by a double-membrane system. The outer membrane of mitochondria is smooth and contains many porins - the integral membrane transporters. Porins enable free diffusion of ions and small uncharged molecules through the outer mitochondrial membrane but limit the transport of molecules larger than 5000 Daltons. Further, the outer mitochondrial membrane forms a unique structure called membrane contact sites with other subcellular organelles,...
11.6K