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N-乙半氨酸对初始牙内损伤的作用:一个体外研究

Shaimaa M Mahfouz Omer¹, Randa H El-Sherbiny², Shaimaa S El-Desouky³

¹Pediatric Dentistry, Preventive Dentistry, and Dental Public Health Department, Faculty of Dentistry, Suez Canal University, Ismailia, Egypt.

BMC oral health

|July 25, 2023

概括

N-乙半氨酸 (NAC) 对初始牙中早期的牙质损伤有负面影响. 长时间暴露于NAC导致了显著的面膜去矿化和矿物质含量变化,表明了有害影响.

科学领域:

牙科研究牙科研究
皮肤病学皮肤病学皮肤病学
材料科学材料科学材料科学

背景情况:

牙损始于非腔化质病变.
N-乙半氨酸 (NAC) 可能具有病性潜力,这取决于其使用频率和形式.
了解NAC对早期膜病变的影响对于预防性牙科至关重要.

研究的目的:

评估N-乙半氨酸 (NAC) 暴露时间对初始牙牙内类似损伤的影响.
用扫描电子显微镜 (SEM) 评估形态变化.
使用能量分散式X射线光谱 (EDX) 分析矿物质含量变化.

主要方法:

40个主要的切口经历了去矿化,以产生状病变.
样品经过1至3个月的N-乙半氨酸 (NAC) 治疗,进行pH循环.
使用SEM和EDX进行的形态和元素分析,通过ANOVA和Bonferroni后期测试进行统计分析.

主要成果:

三个月用NAC治疗的牙表现出严重的牙质结构损失和显著的NAC沉积.
在各组之间,在,,化物,Ca/P比率,碳,和氧含量方面发现了统计学上显著的差异 (P <0.05).
NAC暴露的持续时间与质变化的严重程度相关.

结论:

N-乙半氨酸 (NAC) 表明对人类初始牙中类似于牙皮质损伤的损伤有不利影响.
长时间暴露于NAC会加剧质去矿化,改变矿物成分.
调查结果表明,对于 NAC 在易患牙的儿科牙科患者的使用,需要谨慎.

关键词:

各种乳病变的各种乳病变这是一种N-乙半氨酸 (N-Acetylcysteine).在PH循环循环.一个主要的牙.

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